发明公开
- 专利标题： THERAPEUTIC REGIMEN FOR TREATING CANCER
- 专利标题（中）： 用于局部治疗的药物组合物中高级不能切除的原发性胰腺癌（LAPC）。
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申请号： EP04795677.6申请日： 2004-10-20
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公开(公告)号： EP1687032A1公开(公告)日： 2006-08-09
- 发明人: KESSLER, Paul, D. , RASMUSSEN, Henrik, S. , CHU, Karen, W.
- 申请人： GENVEC, INC.
- 申请人地址： 65 West Watkins Mill Road Gaithersburg, Maryland 20878 US
- 专利权人： GENVEC, INC.
- 当前专利权人： GENVEC, INC.
- 当前专利权人地址： 65 West Watkins Mill Road Gaithersburg, Maryland 20878 US
- 代理机构： Wössner, Gottfried
- 优先权： US520127P 20031114
- 国际公布： WO2005051432 20050609
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C12N15/861 ; C07K14/525
摘要：
The invention provides a method for treating cancer in a human comprising (a) administering to the human a dose of a pharmaceutical composition comprising (i) a pharmaceutically acceptable carrier and (ii) an adenoviral vector comprising a nucleic acid sequence encoding a human TNF-a and operably linked to a promoter, wherein the dose comprises about 4 x 10^7 to about 4 x 10^12 particle units (pu) of adenoviral vector, at least once in a therapeutic period comprising up to about 10 weeks, (b) administering a dose of ionizing radiation to the human over the duration of the therapeutic period, and (c) administering a dose of one or more chemotherapeutics to the human over the duration of the therapeutic period, whereby the cancer in the human is treated.
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