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公开(公告)号：EP1687032A1
公开(公告)日：2006-08-09
申请号：EP04795677.6
申请日：2004-10-20
申请人： GENVEC, INC.
IPC分类号： A61K48/00 , C12N15/861 , C07K14/525
CPC分类号： C12N15/86 , A61K38/212 , A61K48/00 , A61K2121/00 , C07K14/525 , C12N2710/10343 , C12N2830/002 , C12N2830/008 , A61K2300/00
摘要： The invention provides a method for treating cancer in a human comprising (a) administering to the human a dose of a pharmaceutical composition comprising (i) a pharmaceutically acceptable carrier and (ii) an adenoviral vector comprising a nucleic acid sequence encoding a human TNF-a and operably linked to a promoter, wherein the dose comprises about 4 x 10^7 to about 4 x 10^12 particle units (pu) of adenoviral vector, at least once in a therapeutic period comprising up to about 10 weeks, (b) administering a dose of ionizing radiation to the human over the duration of the therapeutic period, and (c) administering a dose of one or more chemotherapeutics to the human over the duration of the therapeutic period, whereby the cancer in the human is treated.
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2.发明授权PHARMACEUTICAL COMPOSITION FOR TREATING UNRESECTABLE, LOCALLY ADVANCED PANCREATIC CANCER (LAPC). 有权药物化合物局部晚期PRIMARY不可操作胰腺癌（LAPC）的治疗。
公开(公告)号：EP1687032B1
公开(公告)日：2010-02-24
申请号：EP04795677.6
申请日：2004-10-20
申请人： GENVEC, INC.
IPC分类号： A61K48/00 , C12N15/861 , C07K14/525
CPC分类号： C12N15/86 , A61K38/212 , A61K48/00 , A61K2121/00 , C07K14/525 , C12N2710/10343 , C12N2830/002 , C12N2830/008 , A61K2300/00
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