发明公开
EP1687294A2 NOVEL PIPERIDINE-SUBSTITUTED INDOLES-OR HETERO-DERIVATIVES THEREOF AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR (CCR-3)
有权
哌啶取代的吲哚衍生物或其HETERO及其作为趋化因子受体（CCR-3）调节剂
- 专利标题： NOVEL PIPERIDINE-SUBSTITUTED INDOLES-OR HETERO-DERIVATIVES THEREOF AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR (CCR-3)
- 专利标题（中）： 哌啶取代的吲哚衍生物或其HETERO及其作为趋化因子受体（CCR-3）调节剂
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申请号： EP04818773.6申请日： 2004-11-11
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公开(公告)号： EP1687294A2公开(公告)日： 2006-08-09
- 发明人: MARTYRES, Domnic , ANDERSKEWITZ, Ralf , DOLLINGER, Horst , POUZET, Pascale , BIRKE, Franz , BOUYSSOU, Thierry
- 申请人： Boehringer Ingelheim International GmbH , Boehringer Ingelheim Pharma GmbH & Co.KG
- 申请人地址： Binger Strasse 173 55216 Ingelheim am Rhein DE
- 专利权人： Boehringer Ingelheim International GmbH,Boehringer Ingelheim Pharma GmbH & Co.KG
- 当前专利权人： Boehringer Ingelheim International GmbH,Boehringer Ingelheim Pharma GmbH & Co.KG
- 当前专利权人地址： Binger Strasse 173 55216 Ingelheim am Rhein DE
- 代理机构： Hammann, Heinz
- 优先权： EP03026170 20031117
- 国际公布： WO2005049559 20050602
- 主分类号： C07D401/04
- IPC分类号： C07D401/04 ; A61K31/454 ; C07D401/14 ; C07D413/14 ; C07D417/14 ; C07D471/04 ; C07D513/04
摘要：
Accordingly, one object of the present invention are novel piperidine-substituted indoles- or heteroderivatives thereof of the formula (1) wherein R1, R5, R6, A, B, D-E, X-W-V, Y, i, j, n and m are defined as below. Another object of the present invention is to provide agonists or antagonists of CCR-3, or pharmaceutically acceptable salts thereof, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.
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