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公开(公告)号：EP1819708A2
公开(公告)日：2007-08-22
申请号：EP05849039.2
申请日：2005-11-25
IPC分类号： C07D475/08 , A61K31/519 , A61P35/00
CPC分类号： C07D475/08
摘要： The invention relates to novel pteridines which can be used in the treatment of respiratory or gastrointestinal complaints or diseases, joint, skin or eye inflammatory diseases, diseases of the periphery or central nervous system or cancer. The invention also relates to pharmaceutical compositions which contain said compounds.
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2.发明公开
公开(公告)号：EP1648888A1
公开(公告)日：2006-04-26
申请号：EP04740684.8
申请日：2004-07-06
发明人： ANDERSKEWITZ, Ralf , BIRKE, Franz , BOUYSSOU, Thierry , DOLLINGER, Horst , MARTYRES, Domnic , POUZET, Pascale, Arielle, Jane-Josee
IPC分类号： C07D451/02 , A61K31/46 , A61P29/00
CPC分类号： C07D451/04 , A61K31/46 , Y02A50/465 , A61K2300/00
摘要： Use of a compound of general formula 1 for manufacturing a medicament to provide agonists or antagonists of CCR-3, or pharmaceutically acceptable salts thereof, in particular compounds of formula 1: wherein R , R , R , A, B, X, W, Z, i, j, k, l and m are defined as in the description and claims. It is another object of the present invention to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP1594873B1
公开(公告)日：2010-12-15
申请号：EP04708347.2
申请日：2004-02-05
发明人： ANDERSKEWITZ, Ralf , DOLLINGER, Horst , HEINE, Claudia , POUZET, Pascale, Arielle, Jane-Josee , BIRKE, Franz , BOUYSSOU, Thierry
IPC分类号： C07D487/04 , C07D471/14
CPC分类号： C07D487/04 , C07D491/14 , C07D495/14
摘要： The invention relates to the novel compounds of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof, wherein the groups Ar1, Ar2, A, R1, R2, R3, E1, E2, X and n are as defined in the description and claims, which are effective modulators of chemokine activity.
摘要翻译： 本发明涉及式（I）的新化合物或其立体异构体或药学上可接受的盐，其中基团Ar1，Ar2，A，R1，R2，R3，E1，E2，X和n如说明书和权利要求书中所定义。 ，它们是趋化因子活性的有效调节剂。
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4.发明公开NOVEL PIPERIDINE-SUBSTITUTED INDOLES-OR HETERO-DERIVATIVES THEREOF AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR (CCR-3) 有权哌啶取代的吲哚衍生物或其HETERO及其作为趋化因子受体（CCR-3）调节剂
公开(公告)号：EP1687294A2
公开(公告)日：2006-08-09
申请号：EP04818773.6
申请日：2004-11-11
发明人： MARTYRES, Domnic , ANDERSKEWITZ, Ralf , DOLLINGER, Horst , POUZET, Pascale , BIRKE, Franz , BOUYSSOU, Thierry
IPC分类号： C07D401/04 , A61K31/454 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/04
CPC分类号： C07D413/14 , A61K31/454 , A61K31/496 , C07D401/04 , C07D401/14 , C07D417/14 , C07D471/04 , C07D513/04
摘要： Accordingly, one object of the present invention are novel piperidine-substituted indoles- or heteroderivatives thereof of the formula (1) wherein R1, R5, R6, A, B, D-E, X-W-V, Y, i, j, n and m are defined as below. Another object of the present invention is to provide agonists or antagonists of CCR-3, or pharmaceutically acceptable salts thereof, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP1660476A1
公开(公告)日：2006-05-31
申请号：EP04764276.4
申请日：2004-08-19
发明人： ANDERSKEWITZ, Ralf , MARTYRES, Domnic , DOLLINGER, Horst , POUZET, Pascale , BIRKE, Franz , BOUYSSOU, Thierry
IPC分类号： C07D401/06 , C07D401/12 , A61K31/4184 , A61K31/45 , A61P37/08 , A61P11/06
CPC分类号： C04B35/632 , C07D401/06 , C07D401/12
摘要： A compound of general formula (1) wherein R1, R5, R6, A, B, Y, i, j and m are defined as in the description and claims. It is another object of the present invention to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.
摘要翻译： 通式（1）的化合物，其中R1，R5，R6，A，B，Y，i，j和m如说明书和权利要求中所定义。 本发明的另一个目的是提供药物组合物，其包含药学上可接受的载体和治疗有效量的至少一种本发明化合物或其药学上可接受的盐。
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公开(公告)号：EP1819708B1
公开(公告)日：2012-01-11
申请号：EP05849039.2
申请日：2005-11-25
IPC分类号： C07D475/08 , A61K31/519 , A61P35/00
CPC分类号： C07D475/08
摘要： The invention relates to novel pteridines which can be used in the treatment of respiratory or gastrointestinal complaints or diseases, joint, skin or eye inflammatory diseases, diseases of the periphery or central nervous system or cancer. The invention also relates to pharmaceutical compositions which contain said compounds.
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7.发明公开SUBSTITUIERTE PTERIDINE ZUR BEHANDLUNG VON ENTZ]NDLICHEN ERKRANKUNGEN 审中-公开取代的蝶啶FOR KEYSTONE]农村疾病治疗
公开(公告)号：EP1828189A1
公开(公告)日：2007-09-05
申请号：EP05813409.9
申请日：2005-11-25
IPC分类号： C07D475/08 , A61K31/519 , A61P11/06
CPC分类号： C07D475/08
摘要： The invention relates to novel pteridines, which are suitable for treating respiratory tract or gastro-intestinal complaints or diseases, inflammatory diseases of the joints, skin, or eyes, diseases of the peripheral or central nervous system, or carcinomas. The invention also relates to pharmaceutical compositions containing said compounds.
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8.发明授权
公开(公告)号：EP1660476B1
公开(公告)日：2006-12-27
申请号：EP04764276.4
申请日：2004-08-19
发明人： ANDERSKEWITZ, Ralf , MARTYRES, Domnic , DOLLINGER, Horst , POUZET, Pascale , BIRKE, Franz , BOUYSSOU, Thierry
IPC分类号： C07D401/06 , C07D401/12 , A61K31/4184 , A61K31/45 , A61P37/08 , A61P11/06
CPC分类号： C04B35/632 , C07D401/06 , C07D401/12
摘要： A compound of general formula (1) wherein R1, R5, R6, A, B, Y, i, j and m are defined as in the description and claims. It is another object of the present invention to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.
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9.发明公开VERWENDUNG VON SUBSTITUIERTEN PYRIMIDO 5,4-D¨PYRIMIDINEN ZUR BEHANDLUNG VON ATEMWEGSERKRANKUNGEN 审中-公开取代的嘧啶并5,4-D¨PYRIMIDINEN的呼吸系统疾病的治疗中
公开(公告)号：EP1708714A1
公开(公告)日：2006-10-11
申请号：EP05700801.3
申请日：2005-01-11
发明人： NICKOLAUS, Peter , MEADE, Christopher, J. Montague , DOLLINGER, Horst , MACK, Jürgen , DAHMANN, Georg , MARTYRES, Domnic , JUNG, Birgit
IPC分类号： A61K31/519 , A61P11/08
CPC分类号： A61K31/519 , A61K31/541 , A61K45/06 , A61K2300/00
摘要： The invention relates to the use of pyrimido[5,4-d]pyrimidines in the treatment of inflammatory and obstructive respiratory tract diseases, preferably asthma or COPD, and pharmaceutical compositions containing said compounds.
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公开(公告)号：EP1594873A1
公开(公告)日：2005-11-16
申请号：EP04708347.2
申请日：2004-02-05
发明人： ANDERSKEWITZ, Ralf , DOLLINGER, Horst , HEINE, Claudia , POUZET, Pascale, Arielle, Jane-Josee , BIRKE, Franz , BOUYSSOU, Thierry
IPC分类号： C07D487/04 , C07D471/14
CPC分类号： C07D487/04 , C07D491/14 , C07D495/14
摘要： The invention relates to the novel compounds of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof, wherein the groups Ar1, Ar2, A, R1, R2, R3, E1, E2, X and n are as defined in the description and claims, which are effective modulators of chemokine activity.
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