发明公开
EP1694664A1 2- ( (2, 3-DIHYDROXYPROPYL) AMINOMETHYL) CHROMANE DERIVATIVES FOR USE AS BETA-3 ADRENORECEPTOR AGONISTS IN THE TREATMENT OF UROLOGICAL AND INFLAMMATORY DISORDERS
审中-公开
2 - （（2，3-二羟基丙基）氨基甲基）苯并二氢吡喃FOR USE ASβ-3肾上腺素受体激动剂炎性疾病和泌尿的治疗
- 专利标题： 2- ( (2, 3-DIHYDROXYPROPYL) AMINOMETHYL) CHROMANE DERIVATIVES FOR USE AS BETA-3 ADRENORECEPTOR AGONISTS IN THE TREATMENT OF UROLOGICAL AND INFLAMMATORY DISORDERS
- 专利标题（中）： 2 - （（2，3-二羟基丙基）氨基甲基）苯并二氢吡喃FOR USE ASβ-3肾上腺素受体激动剂炎性疾病和泌尿的治疗
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申请号： EP04803429.2申请日： 2004-12-02
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公开(公告)号： EP1694664A1公开(公告)日： 2006-08-30
- 发明人: BOYER, Stephen, J. , HASHIMOTO, Kentaro , RÖLLE, Thomas , SANDNER, Peter , STELTE-LUDWIG, Beatrix , TINEL, Hanna , HENNINGER, Kerstin , CONCEPCION, Arnel , SAKURAI, Osamu , HIRAI, Kanako , INOUE, Tadashi , MOCHIZUKI, Yuki , NUNAMI, Noriko , TAJIMI, Masaomi , YAMAMOTO, Noriyuki , TSUKIMI, Yasuhiro
- 申请人： Bayer HealthCare AG
- 申请人地址： 51368 Leverkusen DE
- 专利权人： Bayer HealthCare AG
- 当前专利权人： Bayer HealthCare AG
- 当前专利权人地址： 51368 Leverkusen DE
- 优先权： EP03028781 20031213
- 国际公布： WO2005056544 20050623
- 主分类号： C07D311/58
- IPC分类号： C07D311/58 ; A61K31/353 ; C07D405/12 ; A61K31/403 ; A61K31/4192 ; A61P13/00 ; A61P29/00
摘要：
This invention relates to chroman derivatives of formula (I) and salts thereof which are useful as active ingredients of pharmaceutical preparations. The chroman derivatives of the present invention have an excellent activity as BETA 3 antagonists and are useful for the prophylaxis and treatment of diseases associated with BETA 3 activity, in particular for the treatment of urological disorder or disease, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor overactivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; and inflammatory disorders, such as asthma and COPD.
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