公开(公告)号：EP2144605A1

公开(公告)日：2010-01-20

申请号：EP08749212.0

申请日：2008-04-29

申请人： Bayer HealthCare AG

发明人： SANDNER, Peter ,  TINEL, Hanna ,  STASCH, Johannes-Peter ,  NEUSER, Dieter

IPC分类号： A61K31/194 ,  A61K31/506 ,  A61K31/519 ,  A61K31/53 ,  A61P13/00

CPC分类号： A61K31/506 ,  A61K31/194 ,  A61K31/519 ,  A61K31/53 ,  A61K2300/00

摘要： The invention provides pharmacological compositions comprising a stimulator or activator of the soluble guanylate cyclase alone (sGC) or in combination with a PDE5 inhibitor for the treatment of urological disorders comprising of Benign Prostate Syndrome (BPS), Benign Prostate Hyperplasia (BPH), Benign Prostate Enlargement (BPE), Bladder Outlet Obstruction (BOO), Lower Urinary Tract Symptoms (LUTS), genitourinary disorders comprising neurogenic bladder syndrome (OAB) and (IC), urinary incontinence (UI) like mixed-, urge-, stress-, or overflow incontinence (MUI, UUI, SUI, OUI) and pelvic pain (PP).

公开(公告)号：EP2167057A1

公开(公告)日：2010-03-31

申请号：EP08758921.4

申请日：2008-05-31

申请人： Bayer HealthCare AG

发明人： SANDNER, Peter ,  HÜTTER, Joachim

IPC分类号： A61K31/00 ,  C12Q1/44

CPC分类号： C12Q1/44 ,  A61K31/53 ,  G01N2333/916 ,  G01N2500/04 ,  G01N2800/14

摘要： The invention provides pharmacological compositions comprising PDE-5 inhibitors for the treatment of hearing impairment i.e. hearing loss and tinnitus. The invention also provides methods of screening for such PDE-5 inhibitors for use in the preparation of medicaments for the treatment of hearing impairment i.e. hearing loss and tinnitus.

公开(公告)号：EP1948176A1

公开(公告)日：2008-07-30

申请号：EP06828882.8

申请日：2006-10-30

申请人： Bayer HealthCare AG

发明人： SANDNER, Peter ,  TINEL, Hanna ,  HÜTTER, Joachim ,  RIEDL, Bernd ,  KLEIN, Martina

IPC分类号： A61K31/495 ,  A61P11/00

CPC分类号： A61K31/495

摘要： The present invention relates to pharmaceutical compositions for treating, preventing or managing pulmonary hypertension comprising at least a diaryl urea compound optionally combined with at least one additional therapeutic agent. Useful combinations include e.g. BAY 43-9006 as a diaryl urea compound.

公开(公告)号：EP1948170A1

公开(公告)日：2008-07-30

申请号：EP06818314.4

申请日：2006-10-30

申请人： Bayer HealthCare AG

发明人： SANDNER, Peter ,  TINEL, Hanna ,  HÜTTER, Joachim ,  RIEDL, Bernd ,  KLEIN, Martina

IPC分类号： A61K31/435 ,  A61P11/00

CPC分类号： A61K31/435 ,  Y02A50/423

摘要： The present invention relates to pharmaceutical compositions for treating, preventing or managing pulmonary hypertension comprising 4{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide optionally combined with at least one additional therapeutic agent.

公开(公告)号：EP2037930A1

公开(公告)日：2009-03-25

申请号：EP07764815.2

申请日：2007-06-25

申请人： Bayer HealthCare AG

发明人： VON NUSSBAUM, Franz ,  GIELEN-HAERTWIG, Heike ,  KLEIN, Martina ,  LI, Volkhart, Min-Jian ,  MEIBOM, Daniel ,  SANDNER, Peter ,  LUSTIG, Klemens ,  SCHÄFER, Stefan

IPC分类号： A61K31/513 ,  C07D239/22 ,  C07D401/02

CPC分类号： C07D239/22

摘要： The invention relates to the use of 1,4-diaryl-dihydropyrimidine-2-on derivatives of formula (I) to treat and/or prevent pulmonary arterial hypertension and other forms of pulmonary hypertension, as well as the use thereof for the production of drugs to treat and/or prevent pulmonary arterial hypertension and other forms of pulmonary hypertension.

公开(公告)号：EP2010173A1

公开(公告)日：2009-01-07

申请号：EP07723926.7

申请日：2007-04-03

申请人： Bayer HealthCare AG

发明人： KLEIN, Martina ,  SANDNER, Peter ,  FREY, Reiner ,  RIEDL, Bernd ,  CHRISTENSEN, Olaf

IPC分类号： A61K31/435 ,  A61K31/50 ,  A61K45/06 ,  A61P9/12

CPC分类号： A61K45/06 ,  A61K31/435 ,  A61K31/50 ,  Y02A50/423 ,  A61K2300/00

摘要： The present invention relates to pharmaceutical compositions and combinations for treating, preventing or managing pulmonary hypertension comprising small molecule heterocyclic pharmaceuticals, and more particularly, substituted pyridines and pyridazines optionally combined with at least one additional therapeutic agent.

公开(公告)号：EP1931797A2

公开(公告)日：2008-06-18

申请号：EP06777192.3

申请日：2006-09-16

申请人： Bayer HealthCare AG

发明人： ULBRICH, Ernst ,  SANDNER, Peter ,  TINEL, Hanna ,  HÜTTER, Joachim

IPC分类号： C12Q1/44 ,  A61P13/00 ,  A61K31/00

CPC分类号： C12Q1/44 ,  G01N2500/00

摘要： The invention provides pharmacological compositions comprising PDE-5 and PDE-4 inhibitors, alone or in combination, for the treatment of urological disorders comprising Benign Prostate Hyperplasia (BPH), Lower Urinary Tract Symptoms (LUTS) and in particular irritative symptoms caused by BPH-induced bladder outlet obstruction (BOO). The invention also provides methods of screening for such PDE-5 and PDE-4 inhibitors for use, alone and in combination, in the preparation of medicaments for the treatment of said urological disorders.

公开(公告)号：EP1802600A1

公开(公告)日：2007-07-04

申请号：EP05794912.5

申请日：2005-10-12

申请人： Bayer HealthCare AG

发明人： LAMPE, Thomas ,  ALONSO-ALIJA, Cristina ,  STELTE-LUDWIG, Beatrix ,  SANDNER, Peter ,  BAUSER, Marcus ,  BECK, Hartmut ,  LUSTIG, Klemens ,  ROSENTRETER, Ulrich ,  STAHL, Elke ,  TAKAGI, Hiroko

IPC分类号： C07D333/38 ,  C07D231/14 ,  C07C235/00 ,  A61P13/00

CPC分类号： C07C233/40 ,  C07C233/36 ,  C07C233/37 ,  C07C233/38 ,  C07C233/62 ,  C07C233/73 ,  C07C233/78 ,  C07C271/20 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/10 ,  C07D231/14 ,  C07D333/38

摘要： The present invention relates to novel substituted benzyloxy-phenylmethylamide derivatives of formula (I), processes for their preparation, and their use in medicaments, especially for the prophylaxis and treatment of diseases associated with Cold Menthol Receptor 1 (CMR-1) activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor overactivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD).

摘要翻译： 本发明涉及新的substituiertem苄氧基苯基甲基衍生物，其制备方法，及其在药物中使用，爱尤其用于治疗与冷薄荷醇受体1（CMR-1）的活性，特别是用于治疗相关的疾病的预防和治疗 泌尿科疾病或病症，：如逼尿肌过度活动（膀胱过度活动症），尿失禁，神经原性逼尿肌oeractivity（逼尿肌亢进），特发性逼肌活动过度（逼尿肌不稳定），良性前列腺增生，和下尿路症状; 慢性疼痛，神经性疼痛，术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，痛觉，神经损伤，局部缺血，神经变性，中风，和炎性病症：诸如哮喘和慢性阻塞性肺（或气道）疾病（COPD）。

公开(公告)号：EP1694664A1

公开(公告)日：2006-08-30

申请号：EP04803429.2

申请日：2004-12-02

申请人： Bayer HealthCare AG

发明人： BOYER, Stephen, J. ,  HASHIMOTO, Kentaro ,  RÖLLE, Thomas ,  SANDNER, Peter ,  STELTE-LUDWIG, Beatrix ,  TINEL, Hanna ,  HENNINGER, Kerstin ,  CONCEPCION, Arnel ,  SAKURAI, Osamu ,  HIRAI, Kanako ,  INOUE, Tadashi ,  MOCHIZUKI, Yuki ,  NUNAMI, Noriko ,  TAJIMI, Masaomi ,  YAMAMOTO, Noriyuki ,  TSUKIMI, Yasuhiro

IPC分类号： C07D311/58 ,  A61K31/353 ,  C07D405/12 ,  A61K31/403 ,  A61K31/4192 ,  A61P13/00 ,  A61P29/00

CPC分类号： C07D311/58 ,  C07D405/12

摘要： This invention relates to chroman derivatives of formula (I) and salts thereof which are useful as active ingredients of pharmaceutical preparations. The chroman derivatives of the present invention have an excellent activity as BETA 3 antagonists and are useful for the prophylaxis and treatment of diseases associated with BETA 3 activity, in particular for the treatment of urological disorder or disease, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor overactivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; and inflammatory disorders, such as asthma and COPD.