发明公开
- 专利标题: AMIDOPYRAZOLE DERIVATIVE
- 专利标题(中): 阿米卡唑衍生物
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申请号: EP04807937.0申请日: 2004-12-27
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公开(公告)号: EP1698626A1公开(公告)日: 2006-09-06
- 发明人: KANAYA, Naoaki, Daiichi Pharmaceutical Co., Ltd , ISHIYAMA, Takashi, Daiichi Pharmaceutical Co., Ltd , MUTO, Ryo, c/o Daiichi Pharmaceutical Co., Ltd. , OCHIAI, Yuichi, Daiichi Pharmaceutical Co., Ltd. , WATANABE, Toshiyuki, Daiichi Pharmaceutical Co Ltd , SHIMA Noriko, c/o Iwakura Hospital
- 申请人: DAIICHI PHARMACEUTICAL CO., LTD.
- 申请人地址: 14-10, Nihonbashi 3-chome Chuo-ku, Tokyo 103-8234 JP
- 专利权人: DAIICHI PHARMACEUTICAL CO., LTD.
- 当前专利权人: DAIICHI PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: 14-10, Nihonbashi 3-chome Chuo-ku, Tokyo 103-8234 JP
- 代理机构: Hartz, Nikolai
- 优先权: JP2003434726 20031226; JP2004012154 20040120; JP2004321117 20041104
- 国际公布: WO2005063737 20050714
- 主分类号: C07D401/04
- IPC分类号: C07D401/04 ; C07D401/14 ; C07D405/14 ; C07D417/14 ; A61K31/4439 ; A61K31/444 ; A61K31/497 ; A61K31/501 ; A61P7/02 ; A61P9/10
摘要:
A platelet coagulation inhibitor which inhibits neither COX-1 nor COX-2 is provided. The inhibitor is a compound represented by general formula (I):
wherein Ar 1 and Ar 2 independently represent a 5- or 6-membered aromatic heterocyclic group optionally substituted with 1 to 3 substituents, or a phenyl group optionally substituted with 1 to 3 substituents; R1 represents a lower acyl group, carboxyl group, a lower alkoxycarbonyl group, a lower alkoxy group, a lower alkyl group optionally substituted with 1 or 2 substituents, a carbamoyl group optionally substituted with 1 or 2 substituents, an oxamoyl group optionally substituted with 1 or 2 substituents, an amino group optionally substituted with 1 or 2 substituents, a 4- to 7-membered alicyclic heterocyclic group optionally substituted with 1 or 2 substituents, a phenyl group optionally substituted with 1 to 3 substituents, or a 5- or 6-membered aromatic heterocyclic group optionally substituted with 1 to 3 substituents; and R2 represents hydrogen atom, a halogeno group, or the like.
wherein Ar 1 and Ar 2 independently represent a 5- or 6-membered aromatic heterocyclic group optionally substituted with 1 to 3 substituents, or a phenyl group optionally substituted with 1 to 3 substituents; R1 represents a lower acyl group, carboxyl group, a lower alkoxycarbonyl group, a lower alkoxy group, a lower alkyl group optionally substituted with 1 or 2 substituents, a carbamoyl group optionally substituted with 1 or 2 substituents, an oxamoyl group optionally substituted with 1 or 2 substituents, an amino group optionally substituted with 1 or 2 substituents, a 4- to 7-membered alicyclic heterocyclic group optionally substituted with 1 or 2 substituents, a phenyl group optionally substituted with 1 to 3 substituents, or a 5- or 6-membered aromatic heterocyclic group optionally substituted with 1 to 3 substituents; and R2 represents hydrogen atom, a halogeno group, or the like.
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