公开(公告)号：EP1698626A1

公开(公告)日：2006-09-06

申请号：EP04807937.0

申请日：2004-12-27

申请人： DAIICHI PHARMACEUTICAL CO., LTD.

发明人： KANAYA, Naoaki, Daiichi Pharmaceutical Co., Ltd ,  ISHIYAMA, Takashi, Daiichi Pharmaceutical Co., Ltd ,  MUTO, Ryo, c/o Daiichi Pharmaceutical Co., Ltd. ,  OCHIAI, Yuichi, Daiichi Pharmaceutical Co., Ltd. ,  WATANABE, Toshiyuki, Daiichi Pharmaceutical Co Ltd ,  SHIMA Noriko, c/o Iwakura Hospital

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497 ,  A61K31/501 ,  A61P7/02 ,  A61P9/10

CPC分类号： C07D401/14 ,  C07D401/04 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14

摘要： A platelet coagulation inhibitor which inhibits neither COX-1 nor COX-2 is provided. The inhibitor is a compound represented by general formula (I):

wherein Ar 1 and Ar 2 independently represent a 5- or 6-membered aromatic heterocyclic group optionally substituted with 1 to 3 substituents, or a phenyl group optionally substituted with 1 to 3 substituents; R1 represents a lower acyl group, carboxyl group, a lower alkoxycarbonyl group, a lower alkoxy group, a lower alkyl group optionally substituted with 1 or 2 substituents, a carbamoyl group optionally substituted with 1 or 2 substituents, an oxamoyl group optionally substituted with 1 or 2 substituents, an amino group optionally substituted with 1 or 2 substituents, a 4- to 7-membered alicyclic heterocyclic group optionally substituted with 1 or 2 substituents, a phenyl group optionally substituted with 1 to 3 substituents, or a 5- or 6-membered aromatic heterocyclic group optionally substituted with 1 to 3 substituents; and R2 represents hydrogen atom, a halogeno group, or the like.

摘要翻译： 提供了既不抑制COX-1也不抑制COX-2的血小板凝血抑制剂。 该抑制剂是由通式（I）表示的化合物：其中Ar 1和Ar 2独立地表示任选被1至3个取代基取代的5或6元芳族杂环基或任选被1至3个取代基取代的苯基; R 1表示低级酰基，羧基，低级烷氧基羰基，低级烷氧基，可以被1或2个取代基取代的低级烷基，可以被1或2个取代基取代的氨基甲酰基，可以被1个 或2个取代基，任选被1或2个取代基取代的氨基，任选被1或2个取代基取代的4至7元脂环族杂环基，任选被1至3个取代基取代的苯基或5或6个 任选被1至3个取代基取代的 - 元芳族杂环基团; 并且R2代表氢原子，卤代基团等。