发明公开
EP1706375A2 SUBSTITUTED N-ARYL AMIDINES AS SELECTIVE D1 DOPAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OBESITY AND CNS DISORDERS
审中-公开
取代的N-芳基 - 脒作为选择性多巴胺D1受体拮抗剂用于治疗肥胖和CNS疾病
- 专利标题： SUBSTITUTED N-ARYL AMIDINES AS SELECTIVE D1 DOPAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OBESITY AND CNS DISORDERS
- 专利标题（中）： 取代的N-芳基 - 脒作为选择性多巴胺D1受体拮抗剂用于治疗肥胖和CNS疾病
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申请号： EP04815055.1申请日： 2004-12-21
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公开(公告)号： EP1706375A2公开(公告)日： 2006-10-04
- 发明人: BURNETT, Duane, A. , WU, Wen-Lian , DOMALSKI, Martin, S. , CAPLEN, Mary, Ann , SPRING, Richard , LACHOWICZ, Jean, E.
- 申请人： SCHERING CORPORATION
- 申请人地址： 2000 Galloping Hill Road Kenilworth, New Jersey 07033-0530 US
- 专利权人： SCHERING CORPORATION
- 当前专利权人： SCHERING CORPORATION
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth, New Jersey 07033-0530 US
- 代理机构： Adams, Harvey Vaughan John
- 优先权： US532241P 20031223
- 国际公布： WO2005063697 20050714
- 主分类号： C07C257/14
- IPC分类号： C07C257/14
摘要：
The present invention provides compounds, which, are novel antagonists for D1 receptors as well as methods for preparing such compounds. In another embodiment, the invention provides pharmaceutical compositions comprising such D1 receptor antagonists as well as methods of using them to treat CNS disorders, obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.
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