-
1.发明公开PIPERIDINYL-PIPERIDINE AND PIPERAZINYL-PIPERIDINE FOR USE IN THE TREATMENT OF DIABETES OR PAIN 审中-公开哌啶基哌啶和哌嗪基哌啶糖尿病或疼痛治疗
公开(公告)号：EP2136805A2
公开(公告)日：2009-12-30
申请号：EP08714243.6
申请日：2008-02-27
申请人： Schering Corporation
IPC分类号： A61K31/4545 , A61P3/10 , A61P3/00 , A61P3/08 , A61P25/04 , A61P25/06 , A61P29/00 , A61P29/02
CPC分类号： A61K31/4545 , A61K45/06 , A61K2300/00
摘要： The present invention relates to Compounds of Formula (I), compositions comprising the compounds, and methods of using the compounds to treat or prevent pain, diabetes, a diabetic complication, impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) in a patient.
-
公开(公告)号：EP2114402A2
公开(公告)日：2009-11-11
申请号：EP08714248.5
申请日：2008-02-27
申请人： Schering Corporation
IPC分类号： A61K31/437 , A61K45/06 , A61P3/10 , A61P29/00
CPC分类号： A61K31/437 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compounds of formula (I); compositions comprising the compounds, and methods of using the compounds to treat or prevent pain, diabetes, a diabetic complication, impaired glucose tolerance (IGT) or impaired fasting glucose (IGT) in a patient.
-
3.发明公开
公开(公告)号：EP1965862A2
公开(公告)日：2008-09-10
申请号：EP06847740.5
申请日：2006-12-18
申请人： Schering Corporation
发明人： VAN HEEK, Margaret , HWA, Joyce, J. , GRAZIANO, Michael, P. , LACHOWICZ, Jean, E. , KOWALSKI, Timothy, J. , VELTRI, Enrico, P. , MCCORMICK, Kevin, D. , BERLIN, Michael, Y. , ASLANIAN, Robert, G.
CPC分类号： A61K45/06 , A61K31/00 , A61K31/4178 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , A61K31/4745 , A61K31/496 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising therapeutic combinations comprising: one or more H3 antagonists/inverse agonists; one or more appetite suppressants selected from the group consisting of CBi antagonists/inverse agonists, sibutramine, phentermine and topiramate; and option one or more HMG-CoA reductase inhibitors. The invention also relates to medicaments and kits comprising the pharmaceutical compositions of the present invention, and methods of treating obesity, obesity related disorders and diabetes using the pharmaceutical compositions of the present invention.
-
4.发明公开7-[2-[4-(6-FLUORO-3-METHYL-1,2-BENZISOXAZOL-5-YL)-1-PIPERAZINYL]ETHYL]2-(1-PROPYNYL)-7H-PYRAZOLO-[4,3-e]-[1,2,4]-TRIAZOLO-[1,5-c]-PYRIMIDIN-5 AMINE 有权7-〔2-〔4-（6-氟-3-甲基-1,2-苯并异恶唑-5-基）-1-哌嗪基]乙基] -2-（1-丙炔基）-7H-吡唑并[4， 3-E] - [1,2,4]三唑并[1,5-c]嘧啶-5-胺
公开(公告)号：EP1937687A1
公开(公告)日：2008-07-02
申请号：EP06804036.9
申请日：2006-09-21
申请人： Schering Corporation
IPC分类号： C07D487/14 , A61K31/519 , A61P25/14 , A61P25/16
CPC分类号： C07D487/14
摘要： The compound having the structural formula I, or a pharmaceutically acceptable salt thereof, is disclosed, as well as its use in the treatment of central nervous system diseases, in particular Parkinson's disease, Extra Pyramidal Syndrome, restless legs syndrome and attention deficit hyperactivity disorder, pharmaceutical compositions comprising it, and combinations with other agents.
-
5.发明授权7-[2-[4-(6-FLUORO-3-METHYL-1,2-BENZISOXAZOL-5-YL)-1-PIPERAZINYL]ETHYL]2-(1-PROPYNYL)-7H-PYRAZOLO-[4,3-e]-[1,2,4]-TRIAZOLO-[1,5-c]-PYRIMIDIN-5 AMINE 有权7-〔2-〔4-（6- FLUOR -3-甲基-1,2-苯并异恶唑-5-基）-1-哌嗪基]乙基] -2-（1-丙炔基）-7H-吡唑并[4， 3-E] - [1,2,4]三唑并[1,5-C]嘧啶-5- AMIN
公开(公告)号：EP1937687B1
公开(公告)日：2011-03-30
申请号：EP06804036.9
申请日：2006-09-21
申请人： Schering Corporation
IPC分类号： C07D487/14 , A61K31/519 , A61P25/14 , A61P25/16
CPC分类号： C07D487/14
摘要： The compound having the structural formula I, or a pharmaceutically acceptable salt thereof, is disclosed, as well as its use in the treatment of central nervous system diseases, in particular Parkinson's disease, Extra Pyramidal Syndrome, restless legs syndrome and attention deficit hyperactivity disorder, pharmaceutical compositions comprising it, and combinations with other agents.
-
6.发明公开SUBSTITUTED N-ARYL AMIDINES AS SELECTIVE D1 DOPAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OBESITY AND CNS DISORDERS 审中-公开取代的N-芳基 - 脒作为选择性多巴胺D1受体拮抗剂用于治疗肥胖和CNS疾病
公开(公告)号：EP1706375A2
公开(公告)日：2006-10-04
申请号：EP04815055.1
申请日：2004-12-21
申请人： SCHERING CORPORATION
发明人： BURNETT, Duane, A. , WU, Wen-Lian , DOMALSKI, Martin, S. , CAPLEN, Mary, Ann , SPRING, Richard , LACHOWICZ, Jean, E.
IPC分类号： C07C257/14
CPC分类号： C07D295/205 , A61K45/06 , C07C255/57 , C07C257/14 , C07C257/18 , C07D209/08 , C07D209/86 , C07D211/14 , C07D213/53 , C07D215/26 , C07D215/48 , C07D233/64 , C07D295/073 , C07D295/112 , C07D295/155 , C07D317/58 , C07D319/18 , C07D333/20 , C07D405/12
摘要： The present invention provides compounds, which, are novel antagonists for D1 receptors as well as methods for preparing such compounds. In another embodiment, the invention provides pharmaceutical compositions comprising such D1 receptor antagonists as well as methods of using them to treat CNS disorders, obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.01 秒)
