发明授权
EP1706390B1 ISOXAZOLE DERIVATIVES AND THEIR USE AS CYCLOOXYGENASE INHIBITORS
有权
异恶唑衍生物及其作为环加氧酶抑制剂的用途
- 专利标题： ISOXAZOLE DERIVATIVES AND THEIR USE AS CYCLOOXYGENASE INHIBITORS
- 专利标题（中）： 异恶唑衍生物及其作为环加氧酶抑制剂的用途
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申请号： EP05702217.0申请日： 2005-01-12
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公开(公告)号： EP1706390B1公开(公告)日： 2010-05-19
- 发明人: SCILIMATI, Antonio c/o Dipt. Farmaco-Chimico , DI NUNNO, Leonardo c/o Dipt. Farmaco-Chimico , VITALE, Paola , PATRIGNANI, Paola , TACCONELLI, Stefania , PORRECA, Ettore , STUPPIA, Liborio
- 申请人： Universita' degli Studi di Bari , Universita' Degli Studi di Chieti
- 申请人地址： Palazzo Ateneo, Piazza Umberto I, 1 70121 Bari IT
- 专利权人： Universita' degli Studi di Bari,Universita' Degli Studi di Chieti
- 当前专利权人： Universita' degli Studi di Bari,Universita' Degli Studi di Chieti
- 当前专利权人地址： Palazzo Ateneo, Piazza Umberto I, 1 70121 Bari IT
- 代理机构： Trupiano, Federica
- 优先权： ITMI20040019 20040112
- 国际公布： WO2005068442 20050728
- 主分类号： C07D261/00
- IPC分类号： C07D261/00
摘要：
The present invention refers to isoxazole derivatives, in particular 3,4-diaryl isoxazole derivatives, to their pharmaceutical compositions, the process for preparing them and their use as inhibitors of cycloosygenase, in particular of cycloosygenase 1 and 2 (COX-1) (COX-2). The present invention also refers to a process for determining the potential toxicity of compounds that inhibit cycloosygenase (COX), in particular cycloosygenase-2 (COX-2) isoform, and to the use of compounds that inhibit cycloosygenase (COX), in particular cycloosygenase-2 (COX-2) and their pharmaceutical compositions, in subjects for whom the potential cardiovascular toxicity of said compounds is reduced.
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