公开(公告)号：EP1706390B1

公开(公告)日：2010-05-19

申请号：EP05702217.0

申请日：2005-01-12

申请人： Universita' degli Studi di Bari ,  Universita' Degli Studi di Chieti

发明人： SCILIMATI, Antonio c/o Dipt. Farmaco-Chimico ,  DI NUNNO, Leonardo c/o Dipt. Farmaco-Chimico ,  VITALE, Paola ,  PATRIGNANI, Paola ,  TACCONELLI, Stefania ,  PORRECA, Ettore ,  STUPPIA, Liborio

IPC分类号： C07D261/00

CPC分类号： C07D261/08 ,  C07D413/04

摘要： The present invention refers to isoxazole derivatives, in particular 3,4-diaryl isoxazole derivatives, to their pharmaceutical compositions, the process for preparing them and their use as inhibitors of cycloosygenase, in particular of cycloosygenase 1 and 2 (COX-1) (COX-2). The present invention also refers to a process for determining the potential toxicity of compounds that inhibit cycloosygenase (COX), in particular cycloosygenase-2 (COX-2) isoform, and to the use of compounds that inhibit cycloosygenase (COX), in particular cycloosygenase-2 (COX-2) and their pharmaceutical compositions, in subjects for whom the potential cardiovascular toxicity of said compounds is reduced.