发明公开
- 专利标题： TREATMENT OF MALIGNANT GLIOMAS WITH TGF-BETA INHIBITORS
- 专利标题（中）： 治疗恶性胶质瘤TGF-β抑制剂
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申请号： EP04815564.2申请日： 2004-12-22
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公开(公告)号： EP1708712A1公开(公告)日： 2006-10-11
- 发明人: WELLER, Michael
- 申请人： Scios, Inc.
- 申请人地址： 6500 Paseo Padre Parkway Fremont, CA 94555 US
- 专利权人： Scios, Inc.
- 当前专利权人： Scios, Inc.
- 当前专利权人地址： 6500 Paseo Padre Parkway Fremont, CA 94555 US
- 代理机构： Fisher, Adrian John
- 优先权： US532346P 20031224
- 国际公布： WO2005065691 20050721
- 主分类号： A61K31/517
- IPC分类号： A61K31/517 ; A61K31/53 ; A61K31/505 ; A61P35/00
摘要：
The invention concerns methods of treating malignant gliomas, by administering inhibitors of TGF-β the TGF-β signaling pathway, including molecules preferably binding to the type I TGF-β receptor (TGFβ-R1). Preferably, the inhibitors are non-peptide small molecules, including quinazoline derivatives. The invention also concerns methods for reversing the TGF-β-mediated effect on glioma cells to make them less refractile to signaling and other immune cells, comprising contacting a glioma cell or tissue in vivo or in vitro, with an inhibitor of TGF-β.
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