公开(公告)号：EP1708712A1

公开(公告)日：2006-10-11

申请号：EP04815564.2

申请日：2004-12-22

申请人： Scios, Inc.

发明人： WELLER, Michael

IPC分类号： A61K31/517 ,  A61K31/53 ,  A61K31/505 ,  A61P35/00

CPC分类号： A61K31/519 ,  A61K31/505 ,  A61K31/517 ,  A61K31/53 ,  A61K31/55

摘要： The invention concerns methods of treating malignant gliomas, by administering inhibitors of TGF-β the TGF-β signaling pathway, including molecules preferably binding to the type I TGF-β receptor (TGFβ-R1). Preferably, the inhibitors are non-peptide small molecules, including quinazoline derivatives. The invention also concerns methods for reversing the TGF-β-mediated effect on glioma cells to make them less refractile to signaling and other immune cells, comprising contacting a glioma cell or tissue in vivo or in vitro, with an inhibitor of TGF-β.