发明公开
EP1708758A2 SYSTEM AND METHOD FOR EXPRESSION PROTEOMICS BASED ON ISOTOPE RATIO MODIFICATION
审中-公开
基于该同位素比修正SYSTEM AND METHOD FOR表达蛋白质组学
- 专利标题： SYSTEM AND METHOD FOR EXPRESSION PROTEOMICS BASED ON ISOTOPE RATIO MODIFICATION
- 专利标题（中）： 基于该同位素比修正SYSTEM AND METHOD FOR表达蛋白质组学
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申请号： EP05726264.4申请日： 2005-01-13
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公开(公告)号： EP1708758A2公开(公告)日： 2006-10-11
- 发明人: WHITELEGGE, Julian, P. , AGUS, David, B. , KATZ, Jonathan
- 申请人： Cedars-Sinai Medical Center
- 申请人地址： 8700 Beverly Boulevard Los Angeles, CA 90048 US
- 专利权人： Cedars-Sinai Medical Center
- 当前专利权人： Cedars-Sinai Medical Center
- 当前专利权人地址： 8700 Beverly Boulevard Los Angeles, CA 90048 US
- 代理机构： Banford, Paul Clifford
- 优先权： US536766P 20040115
- 国际公布： WO2005069891 20050804
- 主分类号： A61K51/00
- IPC分类号： A61K51/00 ; A61B5/055 ; C07C331/16
摘要：
The present invention relates to modification of isotope ratios in peptides and polypeptides as an alternative to full isotopic exchange for coding in proteomics. Subtle modification of isotope ratio does not compromise protein identification experiments and can thus provide elemental composition data for accurate isotope ratio decoding. Application of subtle modification of isotope ratio proteomics (SMIRP) offers a convenient approach to in vivo isotope coding.
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