公开(公告)号：EP4510915A1

公开(公告)日：2025-02-26

申请号：EP23792714.0

申请日：2023-04-18

Applicant: Cedars-Sinai Medical Center

Inventor： PIMENTEL, Mark ,  LEITE, Gabriela ,  MATHUR, Ruchi ,  REZAIE, Ali ,  MORALES, Walter ,  WEITSMAN, Stacy

IPC: A61B5/00 ,  A61P1/12 ,  G01N33/497

公开(公告)号：EP4486917A2

公开(公告)日：2025-01-08

申请号：EP23764135.2

申请日：2023-03-02

Applicant: Cedars-Sinai Medical Center ,  The Board of Trustees of the Leland Stanford Junior University

Inventor： HITCHINS, Megan P. ,  HAILE, Robert W. ,  GONG, Jun ,  HENDIFAR, Andrew ,  SNYDER, Michael ,  LEE, Hayan

IPC: C12Q1/6858 ,  C12Q1/6886 ,  C12Q1/68

公开(公告)号：EP4460321A2

公开(公告)日：2024-11-13

申请号：EP23737737.9

申请日：2023-01-05

Applicant: Cedars-Sinai Medical Center

Inventor： KIM, Hyung L. ,  WANG, Yanping ,  SU, Shengchen

IPC: A61K38/17 ,  A61K31/454 ,  C07K14/17 ,  C07D401/04 ,  A61K38/53

公开(公告)号：EP4430381A1

公开(公告)日：2024-09-18

申请号：EP22893895.7

申请日：2022-11-11

Applicant: Black Light Surgical, Inc. ,  Cedars-Sinai Medical Center

Inventor： BORTNIK, Bartosz ,  BUTTE, Pramod ,  O'BRIEN, Mike ,  YU GU, Ruo ,  LOWELL, Augustus P. ,  HARRIS, Todd L. ,  FORD, Russell B. ,  SOLOMON, Edward G. ,  LEVATICH, Mark ,  SHARMA, Dominic V. ,  MOORE, Steven

IPC: G01N21/64 ,  A61B5/00 ,  G01J3/02 ,  G01J3/10 ,  G01N21/17

CPC classification number: G01N21/6456 ,  G01N21/6408 ,  G01N21/6486 ,  G01J3/4406 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/0248 ,  G01J3/28

公开(公告)号：EP4265716A3

公开(公告)日：2024-01-24

申请号：EP23184643.7

申请日：2017-06-16

Applicant: Cedars-Sinai Medical Center

Inventor： SAREEN, Dhruv ,  ORNELAS, Loren A ,  SVENDSEN, Clive

IPC: C12N5/074 ,  C12N15/09 ,  C12N5/10

Abstract: Described herein are methods and compositions related to generation of induced pluripotent stem cells (iPSCs). Improved techniques for establishing highly efficient, reproducible reprogramming using non-integrating episomal plasmid vectors. Using the described reprogramming protocol, one is able to consistently reprogram non-T cells with close to 100% success from non-T cell or non-B cell sources. Further advantages include use of a defined reprogramming media E7 and using defined clinically compatible substrate recombinant human L-521. Generation of iPSCs from these blood cell sources allows for recapitulation of the entire genomic repertoire, preservation of genomic fidelity and enhanced genomic stability.

公开(公告)号：EP4296285A2

公开(公告)日：2023-12-27

申请号：EP23192639.5

申请日：2019-04-26

Applicant: Cedars-Sinai Medical Center ,  Prometheus Biosciences, Inc. ,  Dr. Falk Pharma GmbH

Inventor： BILSBOROUGH, Janine ,  MCGOVERN, Dermot P. ,  TARGAN, Stephan ,  POTDAR, Alka ,  WATKINS, Jeffry, D. ,  DICKERSON, Cindy, T.

IPC: C07K16/28

Abstract: Described herein are methods and systems for identifying subjects suitable for treatment with an inhibitor of CD30L activity or expression, such as an anti-CD30L antibody. Methods and systems disclosed herein identify subjects suitable for treatment based on a presence of a genotype that is indicative of a disease or condition in the subject for which an inhibitor of CD30L is a suitable treatment. Exemplary conditions include both Crohn's disease and primary sclerosing cholangitis. Compositions used to detect the genotypes described herein, and methods of using them are also provided.

公开(公告)号：EP4263585A1

公开(公告)日：2023-10-25

申请号：EP21911988.0

申请日：2021-12-20

Applicant: Cedars-Sinai Medical Center

Inventor： MCGOVERN, Dermot, P. ,  BILSBOROUGH, Janine ,  TARGAN, Stephan, R. ,  POTDAR, Alka

IPC: C07K14/525 ,  C12Q1/6883 ,  A61P1/00

公开(公告)号：EP4256086A1

公开(公告)日：2023-10-11

申请号：EP21901329.9

申请日：2021-11-30

Applicant: Cedars-Sinai Medical Center

Inventor： GONSKY, Rebecca ,  POTDAR, Alka

IPC: C12Q1/6883 ,  G16B15/20 ,  G16B40/20

公开(公告)号：EP4218775A1

公开(公告)日：2023-08-02

申请号：EP23177120.5

申请日：2018-08-02

Applicant: Cedars-Sinai Medical Center

Inventor： MARBAN, Eduardo ,  GRIGORIAN, Lilian

IPC: A61K35/12 ,  A61K35/34 ,  A61K35/545 ,  A61K48/00 ,  C12N5/095 ,  G01N33/574 ,  A61P35/00

Abstract: Described herein are methods and compositions related to treating cancer using cardiosphere derived cells (CDCs) and/or extracellular vesicles (EVs). In some embodiments, the EVs are heart-derived EVs (e.g., cardiosphere-derived exosomes, CDC-derived exosomes, cardiosphere-derived microvesicles, CDC-derived microvesicles, or combinations thereof). In some embodiments, methods of treating cancer in a subject are provided. In some embodiments, CDCs and/or EVs are administered to a subject to treat cancer. In some embodiments, the CDCs and/or EVs are provided in a pharmaceutical formulation.

公开(公告)号：EP4196212A1

公开(公告)日：2023-06-21

申请号：EP21856823.6

申请日：2021-08-13

Applicant: Cedars-Sinai Medical Center

Inventor： REZAIE, Ali ,  PIMENTEL, Mark ,  MELMED, Gil Y.

IPC: A61N5/06 ,  A61M39/16 ,  A61B1/06 ,  A61B18/18 ,  A61B18/24 ,  A61L2/10