发明授权
EP1715042B1 EPITOPE/PEPTIDE RECOGNIZED BY HLA-A2402-RESTRICTED Ep-CAM-SPECIFIC CTL AND USE OF THE SAME
有权
由HLA-A2402-限制的Ep-CAM特异性CTL表位的认可/肽及其用途
- 专利标题： EPITOPE/PEPTIDE RECOGNIZED BY HLA-A2402-RESTRICTED Ep-CAM-SPECIFIC CTL AND USE OF THE SAME
- 专利标题（中）： 由HLA-A2402-限制的Ep-CAM特异性CTL表位的认可/肽及其用途
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申请号： EP05703824.2申请日： 2005-01-19
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公开(公告)号： EP1715042B1公开(公告)日： 2012-08-22
- 发明人: KUZUSHIMA, Kiyotaka c/o Division of Immunology
- 申请人： Aichi Prefecture , OTSUKA PHARMACEUTICAL CO., LTD.
- 申请人地址： 1-2, 3-chome, Sannomaru, Naka-ku Nagoya-shi, Aichi 460-8501 JP
- 专利权人： Aichi Prefecture,OTSUKA PHARMACEUTICAL CO., LTD.
- 当前专利权人： Aichi Prefecture,OTSUKA PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： 1-2, 3-chome, Sannomaru, Naka-ku Nagoya-shi, Aichi 460-8501 JP
- 代理机构： HOFFMANN EITLE
- 优先权： JP2004011752 20040120
- 国际公布： WO2005068632 20050728
- 主分类号： C07K7/06
- IPC分类号： C07K7/06 ; C07K14/74 ; A61K38/04
摘要：
A peptide comprising the amino acid sequence represented by SEQ ID NO:1; a peptide comprising the amino acid sequence represented by SEQ ID NO:2; or a mutant peptide comprising an amino acid sequence derived from an amino acid sequence represented by SEQ ID NO:1 or 2 by addition, deletion or substitution of one or more amino acids and being capable of forming a complex with an HLA-A2402 molecule that can be recognized by HLA-A2402-restricted cytotoxic T lymphocytes or being capable of inducing the same. Such a peptide is useful as a cancer vaccine for epithelial cancer patients having HLA-A2402.
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