公开(公告)号：EP2295605B1

公开(公告)日：2012-08-22

申请号：EP10182585.9

申请日：2004-12-10

申请人： Aichi Prefecture ,  FUJIFILM Corporation

发明人： Takahashi, Takashi ,  Tomita, Shuta ,  Mitsudomi, Tetsuya ,  Yatabe, Yasushi ,  Ogura, Nobuhiko ,  Some, Masato

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158

公开(公告)号：EP1829967A4

公开(公告)日：2008-04-23

申请号：EP05811803

申请日：2005-12-05

申请人： AICHI PREFECTURE ,  NGK INSULATORS LTD

发明人： SETO MASAO ,  TAGAWA HIROYUKI ,  YOSHIDA YASUKO ,  KIRA SHIGEKI

IPC分类号： C12N15/09 ,  A61K48/00 ,  A61P35/00 ,  C12M1/00 ,  C12Q1/68 ,  G01N33/543

CPC分类号： G01N33/57426 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/16

摘要： In order to more accurately analyze a change in the complicated gene copy number in malignant lymphoma and identify a site suffering from an important genomic abnormality in greater detail to thereby employing the results in diagnosing a disease type or estimating the prognosis, genome-wide array CGH is carried out and thus human chromosome 1 p36.23 to p36.32, human chromosome 1 q42.2 t q43, human chromosome 2 p11.2, human chromosome 2 q13, human chromosome 17 p11.2 to p13.3 and human chromosome 19 p13.2 to p13.3 are identified.

公开(公告)号：EP1870091A1

公开(公告)日：2007-12-26

申请号：EP06730431.1

申请日：2006-03-29

申请人： TOKAI UNIVERSITY EDUCATIONAL SYSTEM ,  Aichi Prefecture

发明人： KOJIMA, Naoya ,  IKEHARA, Yuzuru ,  TSUJIMURA, Kunio

IPC分类号： A61K9/127 ,  A61K39/00 ,  A61K47/26 ,  A61K47/36 ,  A61P35/00 ,  A61P37/04

CPC分类号： A61K39/39 ,  A61K9/127 ,  A61K2039/55555

摘要： It is an object of the present invention to provide a liposome composition which is able to allow the MHC class I and class II molecules of antigen-presenting cells to efficiently present an antigen substance. The present invention provides a liposome composition, which comprises an oligosaccharide-coated liposome and an antigen substance and is used to cause the MHC class I and class II molecules of an antigen-presenting cell to present an antigen peptide.

摘要翻译： 本发明的目的是提供能够使抗原呈递细胞的MHC I类和II类分子有效地呈递抗原物质的脂质体组合物。 本发明提供脂质体组合物，其包含寡糖包被的脂质体和抗原物质，并且用于使抗原呈递细胞的MHC I类和II类分子呈递抗原肽。

公开(公告)号：EP1829967A1

公开(公告)日：2007-09-05

申请号：EP05811803.5

申请日：2005-12-05

申请人： Aichi Prefecture ,  NGK INSULATORS, LTD.

发明人： SETO, Masao ,  TAGAWA, Hiroyuki, Nabeyaueno Apt ,  YOSHIDA, Yasuko, NGK INSULATORS, LTD. ,  KIRA, Shigeki, NGK INSULATORS, LTD.

IPC分类号： C12N15/09 ,  A61K48/00 ,  A61P35/00 ,  C12M1/00 ,  C12Q1/68 ,  G01N33/543

CPC分类号： G01N33/57426 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/16

摘要： In order to more accurately analyze a change in the complicated gene copy number in malignant lymphoma and identify a region affected by an important genomic aberration in greater detail so that the results can be used in diagnosing the type of disease and performing prognosis, genome-wide array CGH is carried out and thus human chromosome 1 36.23 to p36.32, human chromosome 1 q42.2 to q43, human chromosome 2 p11.2, human chromosome 2 q13, human chromosome 17 p11.2 to p13.3, and human chromosome 19 p13.2 to p13.3 are identified.

摘要翻译： 为了更准确地分析恶性淋巴瘤中复杂基因拷贝数的变化，并更详细地鉴定受重要基因组畸变影响的区域，使得结果可用于诊断疾病的类型和进行预后，全基因组 进行阵列CGH，因此人染色体1 36.23至p36.32，人染色体1 q42.2至q43，人染色体2 p11.2，人染色体2 q13，人染色体17 p11.2至p13.3和人 染色体19 p13.2至p13.3被鉴定。

公开(公告)号：EP1865325B1

公开(公告)日：2012-05-16

申请号：EP05816850.1

申请日：2005-12-15

申请人： Japan Science and Technology Agency ,  Local Government of Aichi Prefecture ,  WAKO PURE CHEMICAL INDUSTRIES LIMITED

发明人： KANNAGI, Reiji ,  IZAWA, Mineko ,  KIMURA, Naoko ,  KUREI, Shunsuke ,  WATANABE, Kazue

IPC分类号： G01N33/574 ,  C07K16/30

CPC分类号： C07K16/40 ,  C07K16/3076 ,  G01N33/57407 ,  G01N2333/91194 ,  G01N2400/02

摘要： [PROBLEMS] To provide a method of screening, and a test agent, capable of detecting cancer patients and patients with a high risk of cancer at high percentage. [MEANS FOR SOLVING PROBLEMS] A remarkable difference in the distribution of sugar chain sulfating enzyme GlcNAc-6-sulfotransferase isozymes has been found between noncancerous tissues and cancer/adenoma tissues. By the use of the same, it has been clarified that cancer and adenoma (excluding colon cancer and colon adenoma) can be specifically detected through detection of a given range of GlcNAc-6-sulfated sugar chains from patient tissues or fecal specimens. Cancer and adenoma screening can be carried out by the use of an antibody capable of reacting with GlcNAc-6-sufated sugar chains specifically formed by enzymes occurring in cancer and adenoma tissues.

公开(公告)号：EP1795615B1

公开(公告)日：2010-11-03

申请号：EP07006700.4

申请日：2004-12-10

申请人： Aichi Prefecture ,  FUJIFILM Corporation

发明人： Takahashi, Takashi ,  Tomita, Shuta ,  Mitsudomi, Tetsuya ,  Yatabe, Yasushi ,  Ogura, Nobuhiko ,  Some, Masato

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158

公开(公告)号：EP2011906A4

公开(公告)日：2009-12-02

申请号：EP07742102

申请日：2007-04-20

申请人： AICHI PREFECTURE ,  GUNZE KK

发明人： HIRAISHI NAOKO ,  TANAKA TOSHIYUKI ,  TSUKADA SHOICHI

IPC分类号： D01F8/12 ,  D01F8/14

CPC分类号： D01F8/04 ,  Y10T428/2929

公开(公告)号：EP1715042A4

公开(公告)日：2008-01-09

申请号：EP05703824

申请日：2005-01-19

申请人： AICHI PREFECTURE ,  OTSUKA PHARMA CO LTD

发明人： KUZUSHIMA KIYOTAKA

IPC分类号： C12N15/12 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61P35/00 ,  A61P43/00 ,  C07K7/06 ,  C07K14/47 ,  C07K14/705 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/06 ,  C12N5/10 ,  C12P21/02 ,  C12Q1/02

CPC分类号： A61K31/7088 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4748

摘要： A peptide comprising the amino acid sequence represented by SEQ ID NO:1; a peptide comprising the amino acid sequence represented by SEQ ID NO:2; or a mutant peptide comprising an amino acid sequence derived from an amino acid sequence represented by SEQ ID NO:1 or 2 by addition, deletion or substitution of one or more amino acids and being capable of forming a complex with an HLA-A2402 molecule that can be recognized by HLA-A2402-restricted cytotoxic T lymphocytes or being capable of inducing the same. Such a peptide is useful as a cancer vaccine for epithelial cancer patients having HLA-A2402.

公开(公告)号：EP1676914A4

公开(公告)日：2007-10-10

申请号：EP04773479

申请日：2004-09-22

申请人： AICHI PREFECTURE ,  NGK INSULATORS LTD

发明人： SETO MASAO ,  TAGAWA HIROYUKI ,  YOSHIDA YASUKO ,  KIRA SHIGEKI

IPC分类号： C12N15/11 ,  C07K16/18 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6841 ,  C12Q2600/118 ,  C12Q2600/178

摘要： It is intended to provide a method of assessing prognoses of CD5+DLBCL patients and CD5-DLBCL patients. By examining chromosomal DNAs of patients suffering from lymphoma, (1) a CD5+DLBCL patient showing an amplification in the 13q21.1-l31.3 region is judged as having a poor prognosis; (2) a CD5+DLBCL patient showing a deletion in the 1p36.21-p36.13 region is judged as having a poor prognosis; and (3) a CD5-DLBCL patient showing an amplification in the 5p15.33-p14.2 region is judged as having a good diagnosis.

公开(公告)号：EP1795615A3

公开(公告)日：2007-09-26

申请号：EP07006700.4

申请日：2004-12-10

申请人： Aichi Prefecture ,  FUJIFILM Corporation

发明人： Takahashi, Takashi National University Corporation Nagoya Universtiy ,  Tomita, Shuta National University Corporation Nagoya University ,  Mitsudomi, Tetsuya Aichi Cancer Center ,  Yatabe, Yasushi Aichi Cancer Center ,  Ogura, Nobuhiko FUJIFILM Corporation ,  Some, Masato FUJIFILM Corporation

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158

摘要： The present invention provides a method of confirming the gene expression, useful in the decision of a five year survival rate of a patient with lung cancer and the use of a DNA probe kit in the method.
A method useful in the decision of a survival rate of a patient with non-small cell lung cancer comprising confirming the expression strength of at least one gene selected from the group consisting of in lung cancer tissues isolated from the patient.