发明授权
- 专利标题： METHOD FOR THE SEPARATION OF INTERMEDIATES WHICH MAY BE USED FOR THE PREPARATION OF ESCITALOPRAM
- 专利标题（中）： 用于分离的中间体，以产生艾司西酞普兰中使用
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申请号： EP05700625.6申请日： 2005-02-02
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公开(公告)号： EP1716108B1公开(公告)日： 2008-10-15
- 发明人: LYNGSO, Lars Ole
- 申请人： H. LUNDBECK A/S
- 申请人地址： Ottiliavej 9 2500 Valby-Copenhagen DK
- 专利权人： H. LUNDBECK A/S
- 当前专利权人： H. LUNDBECK A/S
- 当前专利权人地址： Ottiliavej 9 2500 Valby-Copenhagen DK
- 代理机构： Meidahl Petersen, John
- 优先权： DK200400217 20040212; US544970P 20040212
- 国际公布： WO2005077891 20050825
- 主分类号： C07C253/34
- IPC分类号： C07C253/34 ; C07C253/30 ; C07C255/59 ; C07D307/87
摘要：
The invention relates to a method of separating and isolating an acylated derivative of 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl]-3-hydroxymethylbenzonitrile by reaction of a mixture of the 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxy-butyl]-3-hydroxymethylbenzonitrile and an acylated derivative thereof with a compound which form a derivative of the 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxy-butyl]-3-hydroxymethylbenzonitrile containing a carboxylic acid group. The acylated derivative containing a carboxylic acid group precipitates once it is formed and may easily be separated from the reaction mixture.
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