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1.发明公开SUCCINATE AND MALONATE SALT OF TRANS-4-(IR,3S)-6-CHLORO-3-PHENYLINDAN-1-YL)-1,2,2-TRIMETHYLPIPERAZINE AND THE USE AS A MEDICAMENT 有权琥珀酸盐和反式-4-（1R，3S）-6-氯-3-苯基茚满-1-基）-1,2,2-三甲基哌嗪丙二酸盐和作为药物的用途
公开(公告)号：EP1658277A1
公开(公告)日：2006-05-24
申请号：EP04762772.4
申请日：2004-08-18
申请人： H. LUNDBECK A/S
发明人： LOPEZ DE DIEGO, Heidi , NIELSEN, Ole , RINGGARD, Lone, Munch , SVANE, Henrik , DAHL, Allan, Carsten , HOWELLS, Mark , BANG-ANDERSEN, Benny , LYNGSO, Lars Ole
IPC分类号： C07D295/06 , C07C35/32 , C07C25/22 , C12P7/02 , C12P41/00 , A61K31/495 , A61P25/18
CPC分类号： C07D295/073 , C07B2200/07 , C07C17/16 , C07C25/22 , C07C29/143 , C07C35/32 , C07C2602/08 , C07D241/04 , C12P7/22 , C12P41/004 , C07C35/52
摘要： 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine hydrogen succinate or hadrogen malonat, pharmaceutical compositions containing these salts and the medical use thereof, including for the treatment of schizophrenia and other psychotic disorders. Also described are methods for the preparation of 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and medical uses thereof.
摘要翻译： 的化合物，4 - （（1R，3S）-6-氯-3-苯基-1-基）-2,2-二甲基哌嗪和包含该化合物和它的盐，和医药用途，包括用于治疗的盐，药物组合物 精神分裂症和其它精神障碍。
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2.发明授权METHOD FOR THE SEPARATION OF INTERMEDIATES WHICH MAY BE USED FOR THE PREPARATION OF ESCITALOPRAM 有权用于分离的中间体，以产生艾司西酞普兰中使用
公开(公告)号：EP1716108B1
公开(公告)日：2008-10-15
申请号：EP05700625.6
申请日：2005-02-02
申请人： H. LUNDBECK A/S
发明人： LYNGSO, Lars Ole
IPC分类号： C07C253/34 , C07C253/30 , C07C255/59 , C07D307/87
CPC分类号： C07C253/30 , C07B2200/07 , C07C253/34 , C07D307/87 , C07C255/53 , C07C255/59
摘要： The invention relates to a method of separating and isolating an acylated derivative of 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl]-3-hydroxymethylbenzonitrile by reaction of a mixture of the 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxy-butyl]-3-hydroxymethylbenzonitrile and an acylated derivative thereof with a compound which form a derivative of the 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxy-butyl]-3-hydroxymethylbenzonitrile containing a carboxylic acid group. The acylated derivative containing a carboxylic acid group precipitates once it is formed and may easily be separated from the reaction mixture.
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3.发明授权SUCCINATE AND MALONATE SALT OF TRANS-4-(IR,3S)-6-CHLORO-3-PHENYLINDAN-1-YL)-1,2,2-TRIMETHYLPIPERAZINE AND THE USE AS A MEDICAMENT 有权琥珀酸盐和反式-4-（1R，3S）-6-氯-3-苯基茚满-1-基）-1,2,2-三甲基哌嗪丙二酸盐和作为药物的用途
公开(公告)号：EP1658277B1
公开(公告)日：2012-04-04
申请号：EP04762772.4
申请日：2004-08-18
申请人： H. Lundbeck A/S
发明人： LOPEZ DE DIEGO, Heidi , NIELSEN, Ole , RINGGARD, Lone, Munch , SVANE, Henrik , DAHL, Allan, Carsten , HOWELLS, Mark , BANG-ANDERSEN, Benny , LYNGSO, Lars Ole
IPC分类号： C07D241/04 , C07C17/16 , C12P7/22 , C07C25/22 , C07C35/32 , C12P41/00 , A61K31/495 , A61P25/18 , C07C29/143
CPC分类号： C07D295/073 , C07B2200/07 , C07C17/16 , C07C25/22 , C07C29/143 , C07C35/32 , C07C2602/08 , C07D241/04 , C12P7/22 , C12P41/004 , C07C35/52
摘要： 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine hydrogen succinate or hadrogen malonat, pharmaceutical compositions containing these salts and the medical use thereof, including for the treatment of schizophrenia and other psychotic disorders. Also described are methods for the preparation of 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and medical uses thereof.
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4.发明公开METHOD FOR THE SEPARATION OF INTERMEDIATES WHICH MAY BE USED FOR THE PREPARATION OF ESCITALOPRAM 有权用于分离的中间体，以产生艾司西酞普兰中使用
公开(公告)号：EP1716108A1
公开(公告)日：2006-11-02
申请号：EP05700625.6
申请日：2005-02-02
申请人： H. LUNDBECK A/S
发明人： LYNGSO, Lars Ole
IPC分类号： C07C253/34 , C07C253/30 , C07C255/59 , C07D307/87
CPC分类号： C07C253/30 , C07B2200/07 , C07C253/34 , C07D307/87 , C07C255/53 , C07C255/59
摘要： The invention relates to a method of separating and isolating an acylated derivative of 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl]-3-hydroxymethylbenzonitrile by reaction of a mixture of the 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxy-butyl]-3-hydroxymethylbenzonitrile and an acylated derivative thereof with a compound which form a derivative of the 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxy-butyl]-3-hydroxymethylbenzonitrile containing a carboxylic acid group. The acylated derivative containing a carboxylic acid group precipitates once it is formed and may easily be separated from the reaction mixture.
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