发明公开
EP1716115A2 SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF
有权
ACYLOXYALKYLCARBAMAT前药和中间体的合成方法
- 专利标题： SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF
- 专利标题（中）： ACYLOXYALKYLCARBAMAT前药和中间体的合成方法
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申请号： EP04815821.6申请日： 2004-12-30
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公开(公告)号： EP1716115A2公开(公告)日： 2006-11-02
- 发明人: GALLOP, Mark A. , DAI, Xuedong , SCHEUERMAN, Randall A. , RAILLARD, Stephen P. , MANTHATI, Suresh K. , YAO, Fenmei , PHAN, Thu , LUDWIKOW, Maria , PENG, Ge , BHAT, Seema
- 申请人： Xenoport, Inc.
- 申请人地址： 3410 Central Expressway Santa Clara, CA 95051-0703 US
- 专利权人： Xenoport, Inc.
- 当前专利权人： Xenoport, Inc.
- 当前专利权人地址： 3410 Central Expressway Santa Clara, CA 95051-0703 US
- 代理机构： Wytenburg, Wilhelmus Johannes
- 优先权： US533649P 20031230; US606637P 20040813
- 国际公布： WO2005066122 20050721
- 主分类号： C07D207/40
- IPC分类号： C07D207/40
摘要：
Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
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