发明授权
EP1717229B1 NOVEL CYCLIC COMPOUND HAVING 4-PYRIDYLALKYLTHIO GROUP HAVING (UN)SUBSTITUTED AMINO INTRODUCED THEREIN
有权
与进口4 PYRIDYLALKYLTHIOGRUPPE它(UN)取代的氨基新的循环连接
- 专利标题: NOVEL CYCLIC COMPOUND HAVING 4-PYRIDYLALKYLTHIO GROUP HAVING (UN)SUBSTITUTED AMINO INTRODUCED THEREIN
- 专利标题(中): 与进口4 PYRIDYLALKYLTHIOGRUPPE它(UN)取代的氨基新的循环连接
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申请号: EP05710622.1申请日: 2005-02-17
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公开(公告)号: EP1717229B1公开(公告)日: 2011-06-15
- 发明人: HONDA, Takahiro , TAJIMA, Hisashi , KAWASHIMA, Kenji , OKAMOTO, Kazuyoshi , YAMAMOTO, Minoru , INABA, Takaaki , TAKENO, Yuriko
- 申请人: SANTEN PHARMACEUTICAL CO., LTD.
- 申请人地址: 9-19, Shimoshinjo 3-chome Higashiyodogawa-ku, Osaka-shi, Osaka 533-8651 JP
- 专利权人: SANTEN PHARMACEUTICAL CO., LTD.
- 当前专利权人: SANTEN PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: 9-19, Shimoshinjo 3-chome Higashiyodogawa-ku, Osaka-shi, Osaka 533-8651 JP
- 代理机构: TER MEER - STEINMEISTER & PARTNER GbR
- 优先权: JP2004039862 20040217; JP2004294347 20040906
- 国际公布: WO2005085201 20050915
- 主分类号: C07D213/73
- IPC分类号: C07D213/73 ; A61K31/44 ; A61K31/47 ; A61K31/496 ; A61K31/5377 ; A61K31/54 ; A61P9/10 ; A61P17/06 ; A61P19/02 ; A61P27/02 ; A61P35/00 ; A61P43/00 ; C07D213/74 ; C07D213/75 ; C07D213/82 ; C07D401/12 ; C07D401/14 ; C07D405/14 ; C07D409/12 ; C07D409/14
摘要:
A novel cyclic compound having a 4-pyridylalkylthio group having an (un)substituted amino group introduced therein or a salt of the compound. They are useful as a medicine. The cyclic compound is a compound represented by the following formula [I], which is useful for the treatment of diseases in which angiogenesis participates. In the following formula [I], ring A represents a benzene ring or a 5- or 6-membered aromatic heterocycle optionally fused with a cycloalkane ring; B represents alkylene; R1 and R2 each represents H, (substituted) aryl, (substituted) heterocyclic group, etc.; R3 and R4 each represents H, (substituted) alkyl, (substituted) cycloalkyl, -Z-R5, etc.; R5 represents (substituted) alkyl, (substituted) aryl, (substituted) heterocyclic group, etc.; X and Y each represents H, etc.; Z represents -CO-, -COO-, -CONR6-, -SO2-, etc.; R6 represents H, etc.; p is 0, 1, or 2; and q is 0 or 1.
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