公开(公告)号：EP4511123A1

公开(公告)日：2025-02-26

申请号：EP23792609.2

申请日：2023-04-21

Applicant: Attillaps Holdings Inc.

Inventor： SPALLITTA, Frank Anthony

IPC: A61P27/02 ,  A61K31/33 ,  A61K9/00

公开(公告)号：EP4511063A1

公开(公告)日：2025-02-26

申请号：EP23795518.2

申请日：2023-04-27

Applicant: Beijing Sightnovo Medical Technology Co., Ltd

Inventor： ZHAO, Chan ,  XIA, Chaoran ,  ZHONG, Weixing ,  ZHANG, Miao

IPC: A61K39/395 ,  A61K38/00 ,  A61P27/02

公开(公告)号：EP4510826A1

公开(公告)日：2025-02-26

申请号：EP23792605.0

申请日：2023-04-21

Applicant: University of Iowa Research Foundation ,  Wisconsin Alumni Research Foundation

Inventor： AHERN, Christopher ,  PATTNAIK, Bikash ,  GONG, Shaoqin ,  WANG, Yuyuan

IPC: A01K67/027 ,  A61K31/7105 ,  A61P27/02 ,  C07H21/02 ,  A61K9/51 ,  C12N5/00 ,  C12N15/864

公开(公告)号：EP4494702A3

公开(公告)日：2025-02-26

申请号：EP24196960.9

申请日：2015-06-24

Applicant: The University of Kansas

Inventor： BLAGG, Brian S. J. ,  DOBROWSKY, Rick T. ,  ANYIKA, Mercy

IPC: C07H15/203 ,  C07C233/05 ,  C07D309/10 ,  C07D311/08 ,  C07D307/20 ,  A61P25/00 ,  C07C233/18 ,  C07D311/16 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P25/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P25/28

Abstract: Provided herein are compounds of the formula:

wherein: n, X 1 , X 2 , R 1 , R 2 , R 3 , R 3 ', R 4 , R 4 ', R 5 , R 5 ', R 6 , and R 6 ' are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases, including diabetic peripheral neuropathy or cancer.

公开(公告)号：EP4509518A1

公开(公告)日：2025-02-19

申请号：EP23786464.0

申请日：2023-04-11

Applicant: Starrygene Therapeutics Co., Ltd.

Inventor： CAI, Yuan ,  ZHU, Ying ,  ZHANG, Jie ,  ZHONG, Guisheng ,  CHU, Cenfeng

IPC: C07K14/015 ,  C12N15/35 ,  C12N15/864 ,  C12N5/10 ,  C12N7/01 ,  A61K38/16 ,  A61K48/00 ,  A61P27/02 ,  A61P27/16

Abstract: The present invention relates to the field of biological medicines. Disclosed are a fusion adeno-associated virus and a use thereof in otological disease and ophthalmic diseases. The fusion adeno-associated virus comprises a fusion peptide fragment formed by fusion of peptide fragments of serotypes AAV1, AAV2, AAV6 and AAV7, or a variant thereof, and can efficiently infect an RPE layer for the treatment of ophthalmic diseases. The fusion adeno-associated virus has a wide application prospect in the treatment of ophthalmic diseases as a safe vector.

公开(公告)号：EP4508043A2

公开(公告)日：2025-02-19

申请号：EP23789159.3

申请日：2023-04-13

Applicant: Mayo Foundation for Medical Education and Research

Inventor： HAAK, Andrew J. ,  BAKRI, Sophie

IPC: C07D313/12 ,  A61K31/55 ,  A61P27/02

公开(公告)号：EP4507786A2

公开(公告)日：2025-02-19

申请号：EP23789141.1

申请日：2023-04-13

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  Karlin, Justin

Inventor： KARLIN, Justin

IPC: A61P27/02 ,  A61F9/007 ,  A61K35/14 ,  A61K38/16

公开(公告)号：EP4504699A1

公开(公告)日：2025-02-12

申请号：EP23719084.8

申请日：2023-03-30

Applicant: Novartis AG

Inventor： CZABANIUK, Lara C. ,  HEDIGER, Michael Christoph ,  HURTH, Konstanze ,  SENDZIK, Martin ,  LABBE-GIGUERE, Nancy ,  VULPETTI, Anna

IPC: C07D209/18 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  A61K31/454 ,  A61K31/41 ,  A61K31/404 ,  A61K31/55 ,  A61P27/02

公开(公告)号：EP4504231A1

公开(公告)日：2025-02-12

申请号：EP23785416.1

申请日：2023-04-07

Applicant: University of North Texas Health Science Center at Fort Worth

Inventor： KARAMICHOS, Dimitrios

IPC: A61K38/16 ,  C07K14/47 ,  A61K9/00 ,  A61P27/02 ,  C07K14/495

公开(公告)号：EP4499847A2

公开(公告)日：2025-02-05

申请号：EP23781793.7

申请日：2023-03-30

Applicant: University of Pittsburgh - of the Commonwealth System of Higher Education

Inventor： THOMAS BYRNE, Leah Caroline ,  JOHNSON, Molly E. ,  STAUFFER, William Richard ,  OZTURK, Bilge Esin

IPC: C12N15/86 ,  A61K48/00 ,  A61P27/02 ,  C07K14/005