发明公开
EP1720836A1 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO [D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS
有权
6-取代的-2,3,4,5-四氢-1H-苯并[d]氮杂作为对5-HT2C受体激动剂
- 专利标题： 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO [D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS
- 专利标题（中）： 6-取代的-2,3,4,5-四氢-1H-苯并[d]氮杂作为对5-HT2C受体激动剂
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申请号： EP05723397.5申请日： 2005-02-18
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公开(公告)号： EP1720836A1公开(公告)日： 2006-11-15
- 发明人: ALLEN, John, Gordon , BRINER, Karin , COHEN, Michael, Philip , GALKA, Christopher, Stanley , HELLMAN, Sarah, Lynne , MARTINEZ-GRAU, Maria Angeles , REINHARD, Matthew, Robert , RODRIGUEZ, Michael, John , ROTHHAAR, Roger, Ryan , TIDWELL, Michael, Wade , VICTOR, Frantz , WILLIAMS, Andrew Caerwyn , ZHANG, Deyi , BOYD, Steven, Armen , CONWAY, Richard, Gerard , DEO, Arundhati, S. , LEE, Wai-Man , SIEDEM, Christopher, Stephen , SINGH, Ajay ,
- 申请人： ELI LILLY AND COMPANY
- 申请人地址： Lilly Corporate Center Indianapolis, Indiana 46285 US
- 专利权人： ELI LILLY AND COMPANY
- 当前专利权人： ELI LILLY AND COMPANY
- 当前专利权人地址： Lilly Corporate Center Indianapolis, Indiana 46285 US
- 代理机构： Suarez-Miles, Ana Sanchiz
- 优先权： US547681P 20040225
- 国际公布： WO2005082859 20050909
- 主分类号： C07D223/16
- IPC分类号： C07D223/16 ; C07D401/12 ; C07D417/12 ; C07D413/12 ; C07D403/12 ; C07D409/12 ; C07D405/12 ; C07D413/14 ; C07D417/06 ; C07D403/06 ; A61K31/55 ; A61P25/22 ; A61P25/24 ; A61P25/30 ; A61P3/04
摘要：
The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT 2C receptor agonists for the treatment of 5-HT 2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: where: R 6 is -S-L-R 15 and other substituents are as defined in the specification.
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