发明公开
- 专利标题： NPC1L1 (NPC3) AND METHODS OF IDENTIFYING LIGANDS THEREOF
- 专利标题（中）： NPC1L1（NPC3）和方法识别其配体的
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申请号： EP05711542申请日： 2005-01-14
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公开(公告)号： EP1723414A4公开(公告)日： 2008-03-26
- 发明人: GARCIA-CALVO MARGARITA
- 申请人： MERCK & CO INC
- 专利权人： MERCK & CO INC
- 当前专利权人： MERCK & CO INC
- 优先权： US53734104 2004-01-16
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; C07K14/705 ; C12Q1/60 ; G01N33/50 ; G01N33/532 ; G01N33/534
摘要：
The present invention provides human, rat and mouse NPCIL1 polypeptides and polynucleotides encoding the polypeptides. Methods for detecting ligands which bind to NPClL1 and block intestinal cholesterol absorption are provided. Also included is a method of identifying ligands which bind to NPCILI using membranes derived from brush border membrane preparations. Compounds that bind to NPCILI can be used for inhibiting intestinal cholesterol absorption in a subject.
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