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    COMPOUNDS FOR TAU PROTEIN DEGRADATION
    1.
    发明公开
    COMPOUNDS FOR TAU PROTEIN DEGRADATION 审中-公开

    公开(公告)号：EP4310496A2

    公开(公告)日：2024-01-24

    申请号：EP23195169.0

    申请日：2018-07-12

    申请人： Dana-Farber Cancer Institute, Inc. ,  The General Hospital Corporation d/b/a Massachusetts General Hospital

    发明人： GRAY, Nathanael S. ,  HAGGARTY, Stephen J. ,  CAI, Quan ,  TELO BAPTISTA LIMA DA SILVA, Maria Catarina ,  ZHANG, Tinghu ,  FERGUSON, Fleur M.

    IPC分类号： G01N33/534

    摘要： Provided herein are bifunctional compounds that bind tau protein and/or promote targeted ubiquitination for the degradation of tau protein. In particular, provided are compounds that can bind tau protein, a protein whose aggregation is implicated in a variety of neurodegenerative disease (e.g., tauopathies), and can promote its degradation by recruiting an E3 ubiquitin ligase (e.g., Cereblon), which can ubiquitinate tau protein, marking it for proteasomal degradation. Also provided are radiolabeled forms of the bifunctional compounds, pharmaceutical compositions comprising the bifunctional compounds, methods of detecting and/or diagnosing neurological disorders, methods of detecting and/or diagnosing pathological aggregation of tau protein (e.g., in the central nervous system), methods of treating and/or preventing neurological disorders, and methods of promoting the degradation of tau protein by E3 ubiquitin ligase activity in a subject by administering a compound or composition described herein.

    IMMUNE COMPLEXES
    7.
    发明公开
    IMMUNE COMPLEXES 审中-公开
    免疫复合物

    公开(公告)号：EP3266465A1

    公开(公告)日：2018-01-10

    申请号：EP16178204.0

    申请日：2016-07-06

    申请人： Julius-Maximilians-Universität Würzburg

    发明人： ALMANZAR, Dr. Giovanni ,  BLEY, Prof. Dr. Thorsten ,  GUTJAHR, Dr. Fabian ,  JAKOB, Prof. Dr. Peter Michael ,  KÖSTLER, Prof. Dr. Herbert ,  KÜRTEN, Prof. Dr. Stefanie ,  PRELOG, Prof. Dr. Martina ,  WECH, Dr. rer. nat. Tobias

    IPC分类号： A61K39/395 ,  A61K51/10 ,  A61K49/00 ,  G01N33/533 ,  G01N33/534

    CPC分类号： G01N33/533 ,  A61K49/1875 ,  C07K16/2866 ,  G01N33/534

    摘要： The invention concerns immune complexes for use in a diagnostic method for detecting and localizing specific cells in a human or animal body by an imaging technique. First antibodies are directed to an antigen located on the surface of said cells. The first antibodies are optionally labeled with first labels. The method comprises that the first antibodies and second antibodies directed to said first antibodies or to the first labels or the first antibodies and ligands specifically binding to the first labels are administered to said human or animal body, wherein said second antibodies or said ligands are labeled with second labels detectable by said imaging technique. The cells are detected and localized in the human or animal body after administration of the first antibodies and second antibodies or of the first antibodies and the ligands by use of the imaging technique. The immune complexes of the invention are formed from the first antibodies and the second antibodies or from the first antibodies and the ligands ex vivo before administration of said immune complexes to the human or animal body.

    摘要翻译： 本发明涉及用于通过成像技术检测和定位人或动物体内特定细胞的诊断方法中的免疫复合物。 第一抗体针对位于所述细胞表面上的抗原。 第一抗体任选用第一标记物标记。 该方法包括将针对所述第一抗体或针对第一标记的第一抗体和第二抗体或针对第一抗体的第一抗体和与第一标记特异性结合的配体给予所述人或动物体，其中所述第二抗体或所述配体被标记 其中第二标签可由所述成像技术检测到。 在通过使用成像技术施用第一抗体和第二抗体或第一抗体和配体后，检测细胞并将其定位在人或动物体内。 本发明的免疫复合物在将所述免疫复合物给予人体或动物体之前由第一抗体和第二抗体或离体的第一抗体和配体形成。

    FUCOIDANS AS LIGANDS FOR THE DIAGNOSIS OF DEGENERATIVE PATHOLOGIES
    9.
    发明公开
    FUCOIDANS AS LIGANDS FOR THE DIAGNOSIS OF DEGENERATIVE PATHOLOGIES 审中-公开
    FUCOIDANE ALS LIGANDEN ZUR DIAGNOSE DEGENERATIVER PATHOLOGIEN

    公开(公告)号：EP3156078A1

    公开(公告)日：2017-04-19

    申请号：EP16191071.6

    申请日：2009-04-10

    申请人： UNIVERSITE PARIS-NORD 13

    发明人： MICHEL, Jean-Baptiste ,  LETOURNEUR, Didier ,  CHAUBET, Frédéric ,  BACHELET, Laure ,  ROUZET, François ,  MEULEMANS, Alain

    IPC分类号： A61K49/00 ,  A61K49/04 ,  A61K49/08 ,  A61K49/22 ,  A61K51/04 ,  A61K51/00 ,  A61K49/12 ,  A61K49/18 ,  A61K51/06 ,  B82Y5/00 ,  G01N33/534

    摘要： The present invention relates to the diagnosis of clinical conditions characterized by undesirable and/or abnormal selectin expression. In particular, the invention provides for the use of fucoidans for the detection of selectins using imaging techniques including ultrasonography, scintigraphy and MRI. Selectin-targeted imaging agents are provided that comprise at least one fucoidan moiety associated with at least one detectable moiety. Methods and kits are described for using these imaging agents in the diagnosis of clinical conditions such as thrombosis, myocardial ischemia/reperfusion injury, stroke and ischemic brain trauma, neurodegenerative disorders, tumor metastasis and tumor growth, and rheumatoid arthritis.

    摘要翻译： 本发明涉及以不良和/或异常选择蛋白表达为特征的临床病症的诊断。 特别地，本发明提供使用岩藻多糖用于使用包括超声，闪烁扫描和MRI的成像技术检测选择素的用途。 提供选择性靶向成像剂，其包含与至少一个可检测部分相关联的至少一个岩藻依聚糖部分。 描述了使用这些成像剂来诊断临床病症如血栓形成，心肌缺血/再灌注损伤，中风和缺血性脑损伤，神经变性障碍，肿瘤转移和肿瘤生长以及类风湿性关节炎的方法和试剂盒。