发明公开
- 专利标题： ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE
- 专利标题（中）： 间变性淋巴瘤激酶调制器和使用方法
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申请号： EP05733275.1申请日： 2005-03-31
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公开(公告)号： EP1730128A1公开(公告)日： 2006-12-13
- 发明人: LEAHY, James William , LEWIS, Gary Lee , NUSS, John M. , RIDGWAY, Brian Hugh , SANGALANG, Joan C.
- 申请人： Exelixis, Inc.
- 申请人地址： 170 Harbor Way, P.O. Box 511 South San Francisco, CA 94083-0511 US
- 专利权人： Exelixis, Inc.
- 当前专利权人： Exelixis, Inc.
- 当前专利权人地址： 170 Harbor Way, P.O. Box 511 South San Francisco, CA 94083-0511 US
- 代理机构： Main, Malcolm Charles
- 优先权： US558800P 20040331
- 国际公布： WO2005097765 20051020
- 主分类号： C07D277/20
- IPC分类号： C07D277/20
摘要：
The present invention relates to compounds of the Formula I, wherein L, X, Y, Z, R1, R2, R3 and R4 are defined herein. The invention also provides methods of using the compounds for inhibition of kinases, more specifically ALK kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions; (Formula I).
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