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    PREDICTING THE ABILITY OF ATLANTIC SALMON TO UTILISE DIETARY PIGMENT BASED ON THE DETERMINATION OF POLYMORPHISMS
    2.
    发明公开
    PREDICTING THE ABILITY OF ATLANTIC SALMON TO UTILISE DIETARY PIGMENT BASED ON THE DETERMINATION OF POLYMORPHISMS 审中-公开
    预测的能力大西洋鲑用食物PIGMENTS基于确定多态性的

    公开(公告)号：EP3155121A1

    公开(公告)日：2017-04-19

    申请号：EP15729908.2

    申请日：2015-06-10

    申请人： Aqua Gen AS

    发明人： LIEN, Sigbjørn ,  SODELAND, Marte ,  MOEN, Thomas

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6827 ,  C12Q2600/124 ,  C12Q2600/156

    摘要： A method of predicting the ability of a salmon to utilise dietary pigment, the method comprising determining the alleles present at one or more DNA polymorphism in the salmon and predicting the ability of the salmon to utilise dietary pigment based on the determination of the alleles. The method may be used for selecting a salmon for use as broodstock. Also contemplated is a method of improving the ability of a salmon to utilise dietary pigment, the method including the step of administering an agent that inhibits the expression of the genes bcmo1-like and/or bcmo1 and/or an agent that inhibits the activities of the proteins Bcmo1-like and/or Bcmo1.

    摘要翻译： 预测鲑鱼的利用膳食颜料的能力的方法，该方法包括确定开采存在于鲑鱼的一个或多个DNA多态性的等位基因和预测的鲑鱼的利用基于所述等位基因的确定膳食颜料的能力。 该方法可以被用于选择鲑用作亲鱼。 所以考虑的是提高鲑鱼的能力利用膳食颜料的方法，包括施用试剂那样的步骤的方法抑制的基因的bcmo1状和/或bcmo1和/或代理确实抑制活动的表达 蛋白质Bcmo1状和/或Bcmo1。

    COMPOSITIONS, SYSTEMS, AND METHODS FOR DETECTING EVENTS USING TETHERS ANCHORED TO OR ADJACENT TO NANOPORES
    3.
    发明公开
    COMPOSITIONS, SYSTEMS, AND METHODS FOR DETECTING EVENTS USING TETHERS ANCHORED TO OR ADJACENT TO NANOPORES 审中-公开
    组合物，事件检测系统及方法，借助系绳参与或偶然的NANO多孔沼地

    公开(公告)号：EP3152320A2

    公开(公告)日：2017-04-12

    申请号：EP15729999.1

    申请日：2015-06-02

    申请人： Illumina, Inc.

    发明人： MANDELL, Jeffrey, G. ,  GUNDERSON, Kevin, L. ,  GUNDLACH, Jens, H.

    IPC分类号： C12Q1/00 ,  C12Q1/68 ,  G01N33/53

    摘要： Compositions, systems, and methods for detecting events are provided. A composition can include a nanopore including a first side, a second side, and an aperture extending through the first and second sides; and a permanent tether including head and tail regions and an elongated body disposed there between. The head region can be anchored to or adjacent to the first or second side of the nanopore. The elongated body including a reporter region can be movable within the aperture responsive to a first event occurring adjacent to the first side of the nanopore. For example, the reporter region is translationally movable toward the first side responsive to the first event, then toward the second side, then toward the first side responsive to a second event. The first event can include adding a first nucleotide to a polynucleotide. The second event can include adding a second nucleotide to the polynucleotide.

    摘要翻译： 组合物，体系和检测事件的方法提供。 的组合物可包括纳米孔包括第一侧，第二侧，并且在孔穿过所述第一侧和第二侧延伸; 和永久系绳包括头部和尾部区域和与细长主体之间布置在那里。 头部区域可以被锚定到或邻近纳米孔的第一或第二侧。 细长主体包括报道分子区域可响应于第一事件的开口内可移动发生的相邻纳米孔的第一侧。 例如，报道分子区域朝向响应于第一事件的第一侧可平移运动，然后向第二侧，然后向响应于第二事件的第一侧。 第一事件可以包括将第一核苷酸的多核苷酸。 第二个事件可以包括添加的第二核苷酸到多核苷酸。

    AN AIR CONDITIONING METHOD USING A STAGED PROCESS USING A LIQUID DESICCANT
    4.
    发明公开
    AN AIR CONDITIONING METHOD USING A STAGED PROCESS USING A LIQUID DESICCANT 审中-公开
    KLIMATISIERUNGSVERFAHREN MIT EINEM GESTUFTEN PROZESS MIT EINEMFLÜSSIGENTROCKNUNGSMITTEL

    公开(公告)号：EP3132206A1

    公开(公告)日：2017-02-22

    申请号：EP15779439.7

    申请日：2015-04-08

    申请人： Mongar, Andrew

    发明人： Mongar, Andrew

    IPC分类号： F24F3/14 ,  F24F11/00

    CPC分类号： F24F3/1417 ,  F24F2003/1458

    摘要： In a process and apparatus of conditioning an airstream, the airstream is contacted with a liquid desiccant absorber in each of at least two stages. The same apparatus is used as an evaporator to reconcentrate the desiccant. The desiccant for each said stage is cooled or heated externally to the absorber or evaporator using an external source of cooling supplied with a common cooling or heating fluid at each stage. The desiccant flows between the stages counter-current to the flow of the airstream such that at each step the concentration of the desiccant is reduced or increased by contact with the airstream so that the concentration in each stage is distinct from the concentration of the desiccant in the previous stages.

    摘要翻译： 在调节气流的方法和装置中，气流在至少两个阶段中的每一个中与液体干燥剂吸收器接触。 使用相同的装置作为蒸发器来再浓缩干燥剂。 每个阶段的干燥剂在每个阶段使用外部供应冷却或加热流体的冷却源冷却或加热到吸收器或蒸发器。 干燥剂在与气流之间逆流的阶段之间流动，使得在每个步骤中，干燥剂的浓度通过与气流接触而降低或增加，使得每个阶段中的浓度不同于干燥剂的浓度 以前的阶段。

    BIOMARKERS OF DE NOVO LIPOGENESIS AND METHODS USING THE SAME
    5.
    发明公开
    BIOMARKERS OF DE NOVO LIPOGENESIS AND METHODS USING THE SAME 有权
    生物标记脂肪酸从头合成和程序

    公开(公告)号：EP3082833A1

    公开(公告)日：2016-10-26

    申请号：EP14870759.9

    申请日：2014-12-18

    申请人： Metabolon, Inc.

    发明人： WATKINS, Steven M.

    IPC分类号： A61K35/60 ,  A61P35/04 ,  G01N33/50

    CPC分类号： G01N33/92 ,  G01N2405/00 ,  G01N2800/7085

    摘要： Biomarkers relating to de novo lipogenesis are provided, as well as methods for using such biomarkers in an Index to assess DNL. In addition, methods for diagnosing, determining predisposition to, and monitoring progression/regression of diseases related to DNL are provided. Also provided are methods of monitoring the efficacy of treatments for diseases related to DNL as well as other methods based on biomarkers of DNL.

    AGONIST FUSION PROTEIN FOR CD40 OX40 AND USES THEREOF
    6.
    发明公开
    AGONIST FUSION PROTEIN FOR CD40 OX40 AND USES THEREOF 审中-公开
    FOR CD40和激动剂融合蛋白​​及其用途OX40

    公开(公告)号：EP2951209A1

    公开(公告)日：2015-12-09

    申请号：EP14745477.1

    申请日：2014-01-31

    申请人： Thomas Jefferson University

    发明人： TYKOCINSKI, Mark, L. ,  WEBER, Matthew, Charles

    IPC分类号： C07K19/00

    CPC分类号： C07K16/2878 ,  A61K39/3955 ,  C07K14/70575 ,  C07K2317/622 ,  C07K2317/75 ,  C07K2319/00

    摘要： Members of the TNF ligand/ TNF receptor superfamily play key roles in a large number of biological events. For instance, members of the TNF ligand/TNF receptor superfamily figure prominently in the complex interplay of positive and negative signals that regulate T cell activation, maintenance of T cell effector function, promotion of maturation of antigen-presenting cells, such as dendritic cells, and the T cell stimulation of APCs. TNF receptors are broadly classified in three groups Receptors in the first group contain a death domain in their cytoplasmic tails. Receptors in the second group contain a TRAF interaction motif in their cytoplasmic tails. The third group of TNF receptors do not contain functional intracellular signaling domains but can act as decoy receptors.

    PD-L1 AND PD-L2-BASED FUSION PROTEINS AND USES THEREOF
    7.
    发明公开
    PD-L1 AND PD-L2-BASED FUSION PROTEINS AND USES THEREOF 审中-公开
    PD-L1- UND PD-L2-BASIERTE FUSIONSPROTEINE UND VERWENDUNGEN DAVON

    公开(公告)号：EP2950814A1

    公开(公告)日：2015-12-09

    申请号：EP14746893.8

    申请日：2014-01-31

    申请人： Thomas Jefferson University

    发明人： TYKOCINSKI, Mark, L.

    IPC分类号： A61K39/00

    CPC分类号： C07K14/70521 ,  A61K38/00 ,  C07K14/525 ,  C07K14/70575 ,  C07K2319/30

    摘要： Provided are fusion proteins comprising a first domain and a second domain, wherein the first domain comprises a polypeptide that binds to and triggers PD-1 and the second domain comprises a polypeptide that binds to and triggers a TRAIL receptor or Fas. In some embodiments, the polypeptide that binds to and triggers PD-1 comprises at least a portion of the extracellular domain of PD-L1 or PD-L2 and the second domain comprises at least a portion of the extracellular domain of TRAIL or Fas ligand. Also provided are methods for treating autoimmune, alloimmune or inflammatory diseases, and methods for treating cancer, using the fusion proteins.

    摘要翻译： 提供了包含第一结构域和第二结构域的融合蛋白，其中第一结构域包含结合并触发PD-1的多肽，并且第二结构域包含结合并触发TRAIL受体或Fas的多肽。 在一些实施方案中，结合并触发PD-1的多肽包含PD-L1或PD-L2的细胞外结构域的至少一部分，第二结构域包含至少一部分TRAIL或Fas配体的细胞外结构域。 还提供了使用融合蛋白治疗自身免疫，同种异体免疫或炎性疾病的方法和用于治疗癌症的方法。

    Biomarkers for fatty liver disease and methods using the same
    9.
    发明公开
    Biomarkers for fatty liver disease and methods using the same 有权
    BiomarkerfürFettlebererkrankung und Verfahren zu deren Verwendung

    公开(公告)号：EP2930512A3

    公开(公告)日：2015-12-02

    申请号：EP15155591.9

    申请日：2008-10-31

    申请人： Metabolon Inc. ,  THE CLEVELAND CLINIC FOUNDATION

    发明人： Berger, Alvin ,  Hu, YunFu ,  Kalhan, Satish C. ,  McCreedy, Bruce J., Jr.

    IPC分类号： G01N33/48

    CPC分类号： G01N33/6893 ,  G01N2500/00 ,  G01N2570/00 ,  G01N2800/085 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/60 ,  H01J49/0027 ,  Y10T436/143333 ,  Y10T436/163333 ,  Y10T436/200833

    摘要： The present invention provides various biomarkers of fatty liver disease, including steatosis and steatohepatitis. The present invention also provides various methods of using the biomarkers, including methods for diagnosis of fatty liver disease, methods of determining predisposition to fatty liver disease, methods of monitoring progression/regression of fatty liver disease, methods of assessing efficacy of compositions for treating fatty liver disease, methods of screening compositions for activity in modulating biomarkers of fatty liver disease, methods of treating fatty liver disease, as well as other methods based on biomarkers of fatty liver disease.

    摘要翻译： 本发明提供脂肪肝疾病的多种生物标志物，包括脂肪变性和脂肪性肝炎。 本发明还提供了使用生物标志物的各种方法，包括用于诊断脂肪肝疾病的方法，确定脂肪肝疾病倾向的方法，监测脂肪肝疾病进展/消退的方法，评估组合物治疗脂肪的功效的方法 肝脏疾病，筛选脂肪肝疾病生物标志物活性组合物的方法，脂肪肝疾病治疗方法以及基于脂肪肝疾病生物标志物的其他方法。