发明公开
EP1730262A2 MODULATION OF CELL INTRINSIC STRAIN TO CONTROL CELL MODULUS, MATRIX SYNTHESIS, SECRETION, ORGANIZATION, MATERIAL PROPERTIES AND REMODELING OF TISSUE ENGINEERED CONSTRUCTS
审中-公开
ZELLINTRINSISCHEN负担的调节控制细胞模块，矩阵合成，分泌，组织和材料特性，通过形成组织工程产生构建体
- 专利标题： MODULATION OF CELL INTRINSIC STRAIN TO CONTROL CELL MODULUS, MATRIX SYNTHESIS, SECRETION, ORGANIZATION, MATERIAL PROPERTIES AND REMODELING OF TISSUE ENGINEERED CONSTRUCTS
- 专利标题（中）： ZELLINTRINSISCHEN负担的调节控制细胞模块，矩阵合成，分泌，组织和材料特性，通过形成组织工程产生构建体
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申请号： EP05725181.1申请日： 2005-03-10
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公开(公告)号： EP1730262A2公开(公告)日： 2006-12-13
- 发明人: BANES, Albert, J.
- 申请人： Medtrain Technologies, LLC , Qi, Jie
- 申请人地址： 437 Dimmocks Mill Road Hillsborough, North Carolina 27278 US
- 专利权人： Medtrain Technologies, LLC,Qi, Jie
- 当前专利权人： Medtrain Technologies, LLC,Qi, Jie
- 当前专利权人地址： 437 Dimmocks Mill Road Hillsborough, North Carolina 27278 US
- 代理机构： Wablat, Wolfgang
- 优先权： US551909P 20040310; US76425 20050309
- 国际公布： WO2005086881 20050922
- 主分类号： C12N5/00
- IPC分类号： C12N5/00 ; C12M1/00
摘要：
The present invention provides methods for manipulating the intrinsic strain of cells by treating tissue engineered constructs or native tissue with compounds which affect the intrinsic strain setpoint of the cells in order to modulate matrix synthesis, secretion, organization and/or remodeling so that the tissues withstand in vivo mechanical forces and have the structural characteristics of host tissue which has been permanently altered by injury, atrophy or disease. The compounds include binding site peptides, ATP, UTP and related analogues, IL-1βb, TGF-α, cytochalasin D, hyaluronic acid, nocodazole and others. Also provided are methods for applying a mechanical external strain to the tissues, as well as methods for modulating the expression of cytoskeletal genes that transcribe cytoskeletal proteins which regulate a cell's intrinsic strain setpoint.
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