发明公开
EP1733738A1 METHOD OF PREVENTING ULTRAVIOLET RAY-INDUCED APOPTOSIS
审中-公开
VERFAHREN ZUR VERHINDERUNG VON DURCH ULTRAVIOLETTE STRAHLUNGAUSGELÖSTERAPOPTOSE
- 专利标题: METHOD OF PREVENTING ULTRAVIOLET RAY-INDUCED APOPTOSIS
- 专利标题(中): VERFAHREN ZUR VERHINDERUNG VON DURCH ULTRAVIOLETTE STRAHLUNGAUSGELÖSTERAPOPTOSE
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申请号: EP05721547.7申请日: 2005-03-18
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公开(公告)号: EP1733738A1公开(公告)日: 2006-12-20
- 发明人: KATAGIRI, Chika c/o SHISEIDO RESEARCH CENTER , HIBINO, Toshihiko c/o SHISEIDO RESEARCH CENTER
- 申请人: SHISEIDO COMPANY, LTD.
- 申请人地址: 5-5 Ginza 7-chome, Chuo-ku Tokyo 104-8010 JP
- 专利权人: SHISEIDO COMPANY, LTD.
- 当前专利权人: SHISEIDO COMPANY, LTD.
- 当前专利权人地址: 5-5 Ginza 7-chome, Chuo-ku Tokyo 104-8010 JP
- 代理机构: Santarelli, Luc
- 优先权: JP2004087051 20040324
- 国际公布: WO2005089801 20050929
- 主分类号: A61K45/00
- IPC分类号: A61K45/00
摘要:
The present invention provides a method for enhancing resistance to the onset of skin damage caused by irradiation of the skin with ultraviolet light by inhibiting ultraviolet irradiation-induced apoptosis of epidermal cells as a result of increasing expression of SCCA-1 and/or SCCA-2 in epidermal cells. Moreover, the present invention provides a skin testing method for evaluating resistance of the skin to skin damage caused by ultraviolet irradiation by measuring the expression of SCCA-1 and/or SCCA-2 in epidermal cells, and judging UV resistance of the epidermis to be weak in the case expression is decreased as compared with expression in epidermal cells. Moreover, the present invention provides a method for screening drugs which enhance resistance of the skin to skin damage by ultraviolet irradiation by selecting a drug that increases expression of SCCA-1 and/or SCCA-2 as a UV resistance enhancer.
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