公开(公告)号：EP1733738A1

公开(公告)日：2006-12-20

申请号：EP05721547.7

申请日：2005-03-18

申请人： SHISEIDO COMPANY, LTD.

发明人： KATAGIRI, Chika c/o SHISEIDO RESEARCH CENTER ,  HIBINO, Toshihiko c/o SHISEIDO RESEARCH CENTER

IPC分类号： A61K45/00

CPC分类号： C07K14/47 ,  A61K8/606 ,  A61K48/00 ,  A61Q17/04 ,  G01N33/6893 ,  G01N2510/00 ,  G01N2800/20

摘要： The present invention provides a method for enhancing resistance to the onset of skin damage caused by irradiation of the skin with ultraviolet light by inhibiting ultraviolet irradiation-induced apoptosis of epidermal cells as a result of increasing expression of SCCA-1 and/or SCCA-2 in epidermal cells. Moreover, the present invention provides a skin testing method for evaluating resistance of the skin to skin damage caused by ultraviolet irradiation by measuring the expression of SCCA-1 and/or SCCA-2 in epidermal cells, and judging UV resistance of the epidermis to be weak in the case expression is decreased as compared with expression in epidermal cells. Moreover, the present invention provides a method for screening drugs which enhance resistance of the skin to skin damage by ultraviolet irradiation by selecting a drug that increases expression of SCCA-1 and/or SCCA-2 as a UV resistance enhancer.

摘要翻译： 本发明提供一种通过抑制紫外线照射诱导的表皮细胞凋亡，由于SCCA-1和/或SCCA-2的表达增加而增强对紫外线照射引起的皮肤损伤发作的抗性的方法 在表皮细胞中。 此外，本发明提供了一种皮肤测试方法，用于通过测量表皮细胞中SCCA-1和/或SCCA-2的表达来评估皮肤对紫外线照射引起的皮肤损伤的抗性，并将表皮的抗紫外线性判断为 与表皮细胞中的表达相比，病例表达较弱。 此外，本发明提供一种通过选择增加作为抗紫外线增强剂的SCCA-1和/或SCCA-2的表达的药物，通过紫外线照射来增强皮肤对皮肤损伤的抗性的药物的方法。