发明公开
- 专利标题： GLYCOL LINKED FGF-21 COMPOUNDS
- 专利标题（中）： 乙二醇联FGF-19连接
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申请号： EP05724363.6申请日： 2005-03-04
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公开(公告)号： EP1735340A2公开(公告)日： 2006-12-27
- 发明人: GLAESNER, Wolfgang , RATHNACHALAM, Radhakrishnan , MILLICAN, Rohn Lee, Jr. , TSCHANG, Sheng-Hung Rainbow
- 申请人： ELI LILLY AND COMPANY
- 申请人地址： Lilly Corporate Center Indianapolis, Indiana 46285 US
- 专利权人： ELI LILLY AND COMPANY
- 当前专利权人： ELI LILLY AND COMPANY
- 当前专利权人地址： Lilly Corporate Center Indianapolis, Indiana 46285 US
- 代理机构： Hiscock, Ian James
- 优先权： US553765P 20040317
- 国际公布： WO2005091944 20051006
- 主分类号： C07K14/435
- IPC分类号： C07K14/435
摘要：
The invention provides FGF-21 compounds covalently attached to at least one polyethylene glycol molecule or derivative thereof, resulting in a biologically active polypeptide with an extended elimination half-life and a slower clearance when compared to that of non-PEGylated polypeptide. These PEGylated FGF-21 compounds and compositions are useful in treating diabetes, obesity, and metabolic syndrome.
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