发明公开
EP1741780A3 High affinity oligonucleotide ligands to growth factors
失效
与生长因子更高的亲和性Ologonukleotidliganden
- 专利标题： High affinity oligonucleotide ligands to growth factors
- 专利标题（中）： 与生长因子更高的亲和性Ologonukleotidliganden
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申请号： EP06021052.3申请日： 1996-05-30
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公开(公告)号： EP1741780A3公开(公告)日： 2007-03-28
- 发明人: Toothman, Penelope J. , Gold, Larry M. , Janjic, Nebojsa , Ringquist, Steven , Pagratis, Nikos
- 申请人： GILEAD SCIENCES, INC.
- 申请人地址： 333 Lakeside Drive Foster City, California 94404 US
- 专利权人： GILEAD SCIENCES, INC.
- 当前专利权人： GILEAD SCIENCES, INC.
- 当前专利权人地址： 333 Lakeside Drive Foster City, California 94404 US
- 代理机构： Clegg, Richard Ian
- 优先权： US458423 19950602; US458424 19950602; US465591 19950605; US465594 19950605; US479725 19950607; US479783 19950607; US618693 19960320
- 主分类号： C12N15/11
- IPC分类号： C12N15/11 ; C12P19/34 ; C12Q1/68
摘要：
Methods are described for the identification and preparation of high-affinity nucleic acid ligands to TGFβ, PDGF and hKGF. Included in the invention are specific RNA and ssDNA ligands to TGFβ1 and PDGF identified by the SELEX method. Also included in the invention are specific RNA ligands to hKGF identified by the SELEX method. Further included are RNA ligands that inhibit the interaction of TGFβ1 and hKGF with their receptors and DNA ligands that inhibit the interaction of PDGF with its receptor.
公开/授权文献
- EP1741780A2 High affinity oligonucleotide ligands to growth factors 公开/授权日：2007-01-10
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