公开(公告)号：EP4403221A2

公开(公告)日：2024-07-24

申请号：EP24169258.1

申请日：2008-02-22

申请人： Gilead Sciences, Inc.

发明人： DESAI, Manoj, C. ,  HONG, Allen, Y. ,  HUI, Hon, C. ,  LIU, Hongtao ,  VIVIAN, Randall, W. ,  XU, Lianhong

IPC分类号： A61P31/00

CPC分类号： A61K31/426 ,  A61K31/427 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  A61P31/00 ,  A61P31/12 ,  A61P31/14 ,  A61P31/18 ,  A61P43/00

摘要： The present application provides for a compound of Formula IV,

or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.

公开(公告)号：EP4382105A2

公开(公告)日：2024-06-12

申请号：EP24158412.7

申请日：2018-08-16

申请人： Gilead Sciences, Inc.

发明人： HOUSTON, Travis, Lee ,  SHI, Bing

IPC分类号： A61K31/454

CPC分类号： C07D401/14 ,  A61P31/18 ,  A61K31/454

摘要： The present disclosure relates to choline salts, and crystalline forms thereof, of a compound which is N-((S)-1-(3-(4-chloro-3-(methylsulfonamido)-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl)-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamide, which is useful in the treatment and prevention of a Retroviridae viral infection including an infection caused by the HIV virus.

公开(公告)号：EP4375279A2

公开(公告)日：2024-05-29

申请号：EP24154495.6

申请日：2020-06-11

申请人： GILEAD SCIENCES, INC.

发明人： CANALES, Eda Y. ,  DESAI, Manoj C. ,  GORMAN, Eric ,  LI, Jiayao ,  SAITO, Roland D. ,  TAYLOR, James G. ,  WRIGHT, Nathan E.

IPC分类号： C07D401/14

CPC分类号： C07D401/14 ,  A61P3/00 ,  A61P35/00 ,  A61P37/00 ,  A61P29/00

摘要： The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) of generic Formula (I) and methods of use and manufacture thereof.

公开(公告)号：EP4371987A1

公开(公告)日：2024-05-22

申请号：EP24150846.4

申请日：2019-10-30

申请人： Gilead Sciences, Inc.

发明人： BALAN, Gayatri ,  BARTLETT, Mark, J. ,  CHANDRASEKHAR, Jayaraman ,  CODELLI, Julian A. ,  CONWAY, John H. ,  COSMAN, Jennifer L. ,  KALLA, Rao V. ,  KASUN, Zachary A. ,  KIM, Musong ,  LEE, Seung H. ,  LO, Jennifer R. ,  LOYER-DREW, Jennifer A. ,  MITCHELL, Scott A. ,  PERRY, Thao D. ,  PHILLIPS, Gary B. ,  SALVO, Patrick J. ,  SWAMINATHAN, Sundaramoorthi ,  VAN VELDHUIZEN, Joshua J. ,  YEUNG, Suet C. ,  ZABLOCKI, Jeff

IPC分类号： C07D471/04 ,  C07D519/00 ,  A61P35/00 ,  A61K31/437

CPC分类号： C07D471/04 ,  C07D519/00 ,  A61P35/00

摘要： The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

公开(公告)号：EP4351657A1

公开(公告)日：2024-04-17

申请号：EP22743641.7

申请日：2022-06-09

申请人： GILEAD SCIENCES, INC.

发明人： KENNEY, Thomas F. ,  MATSON, Clinton K. ,  VENKATARAMANI, Chandrasekar

IPC分类号： A61K47/68 ,  A61P35/00

CPC分类号： A61K47/6803 ,  A61K47/6855 ,  A61P35/00

公开(公告)号：EP4346822A1

公开(公告)日：2024-04-10

申请号：EP22740584.2

申请日：2022-06-02

申请人： GILEAD SCIENCES, INC.

发明人： BRECKENRIDGE, David G. ,  BUDAS, Grant R. ,  GUPTA, Ruchi ,  TAYLOR, James G. ,  WARR, Matthew R. ,  WRIGHT, Nathan E.

IPC分类号： A61K31/4709 ,  A61K31/4725 ,  A61K31/675 ,  A61K45/06 ,  A61K9/00 ,  A61P1/16 ,  A61P43/00

公开(公告)号：EP4346772A1

公开(公告)日：2024-04-10

申请号：EP22735692.0

申请日：2022-05-25

申请人： GILEAD SCIENCES, INC.

发明人： JENSEN, Gerard ,  KIM, Youngri ,  LEE, Kian Yong ,  PHAM, Huy ,  UPTON, Thomas ,  YANG, Stephanie

IPC分类号： A61K9/127 ,  A61K31/706 ,  A61K9/19 ,  A61K47/12 ,  A61K47/26 ,  A61K9/00 ,  A61K31/00

公开(公告)号：EP4337654A1

公开(公告)日：2024-03-20

申请号：EP22727611.0

申请日：2022-05-11

申请人： GILEAD SCIENCES, INC.

发明人： BESTVATER, Brian, P. ,  DU, Zhimin ,  FARAND, Julie ,  VENKATARAMANI, Chandrasekar ,  YANG, Kin, S. ,  ZAGORSKA, Anna

IPC分类号： C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  A61P1/16 ,  A61P9/00 ,  A61P11/00 ,  A61P13/12 ,  A61P29/00 ,  A61P35/00 ,  A61K45/00 ,  A61K31/4439

公开(公告)号：EP4331677A2

公开(公告)日：2024-03-06

申请号：EP23195442.1

申请日：2018-03-13

申请人： Gilead Sciences, Inc. ,  The Regents of The University of California

发明人： PERRON, Michel Joseph ,  PEDERSEN, Niels C.

IPC分类号： A61P31/14

摘要： Provided are methods of treating feline Coronavirus infections comprising administering a therapeutically effective amount of a compound of Compound 1 to Compound 9, or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP4273132A3

公开(公告)日：2024-01-10

申请号：EP23196678.9

申请日：2018-03-02

申请人： Gilead Sciences, Inc.

发明人： GEIER, Michael ,  HUMPHREYS, Luke ,  IKEMOTO, Norihiro ,  LIEW, Sean ,  MORRISON, Henry ,  SCOTT, Mark E. ,  VARGHESE, Vimal

IPC分类号： C07C51/09

摘要： The present disclosure provides solid forms, including a salt or co-crystal, of Compound I:

which exhibits Acetyl-CoA carboxylase ("ACC") inhibitory activity and may be useful in treating ACC mediated diseases. Also provided herein are processes or steps for the preparation of a Compound I and intermediates useful for the processes or steps described herein.