发明授权
- 专利标题: COMPRESSED PHARMACEUTICAL COMPOSITIONS COMPRISING PEG AND ELECTROLYTES
- 专利标题(中): 与PEG和电解质的压制药物组合物
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申请号: EP05735983.8申请日: 2005-04-25
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公开(公告)号: EP1742645B1公开(公告)日: 2011-01-26
- 发明人: Barras, Norman , Cox, Ian
- 申请人: Norgine BV
- 申请人地址: Hogehilweg 7 1101 CA Amsterdam Zuid-Oost NL
- 专利权人: Norgine BV
- 当前专利权人: Norgine BV
- 当前专利权人地址: Hogehilweg 7 1101 CA Amsterdam Zuid-Oost NL
- 代理机构: Brady, Paul Andrew
- 优先权: GB0409104 20040423
- 国际公布: WO2005102364 20051103
- 主分类号: A61K31/765
- IPC分类号: A61K31/765 ; A61P1/10 ; A61K9/20 ; A61K33/14
摘要:
The invention provides a compressed pharmaceutical composition comprising polyethylene glycol of molecular weight from 2000 to 4500, wherein the polyethylene glycol makes up from 80 to 99.5% by weight of the composition, one or more electrolytes for the treatment of constipation, faecal impaction, faecal retention, intestinal gas and cramping, or flatulence; or for orthostatic lavage, colon evacuation or colon cleansing. It has been found, surprisingly, that a compressed pharmaceutical composition comprising PEG for example a solid tablet, is significantly more palatable than previously proposed compositions and is effective when administered. The compressed pharmaceutical composition of the invention comprising polyethylene glycol has been found to have a more agreeable taste and a more agreeable mouthfeel than previously proposed liquid or dry powder or granular compositions.
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