发明公开
EP1745046A2 1 H-INDAZOLES, BENZOTHIAZOLES, 1,2-BENZIOSOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND CHROMONES AND PREPARATION AND USES THEREOF
有权
1H吲唑，苯并噻唑，1,2-苯并异恶唑，1,2-苯并异噻唑及其制备和用途和色酮
- 专利标题： 1 H-INDAZOLES, BENZOTHIAZOLES, 1,2-BENZIOSOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND CHROMONES AND PREPARATION AND USES THEREOF
- 专利标题（中）： 1H吲唑，苯并噻唑，1,2-苯并异恶唑，1,2-苯并异噻唑及其制备和用途和色酮
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申请号： EP05747486.8申请日： 2005-05-06
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公开(公告)号： EP1745046A2公开(公告)日： 2007-01-24
- 发明人: XIE, Wenge , HERBERT, Brian , SCHUMACHER, Richard A. , MA, Jianguo , NGUYEN, Truc, Minh , GAUSS, Carla, Maria , TEHIM, Ashok
- 申请人： Memory Pharmaceuticals Corporation
- 申请人地址： 100 Philips Parkway Montvale, NJ 07645 US
- 专利权人： Memory Pharmaceuticals Corporation
- 当前专利权人： Memory Pharmaceuticals Corporation
- 当前专利权人地址： 100 Philips Parkway Montvale, NJ 07645 US
- 代理机构： Dey, Michael
- 优先权： US568696P 20040507; US574712P 20040527; US626469P 20041110
- 国际公布： WO2005111038 20051124
- 主分类号： C07D471/08
- IPC分类号： C07D471/08 ; C07D487/08 ; A61K31/4985 ; A61K31/551 ; A61P25/28
摘要：
The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
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