发明公开
- 专利标题： KINASE MODULATORS AND METHODS OF USE
- 专利标题（中）： 激酶调节剂及其使用方法
-
申请号： EP05804792.9申请日： 2005-04-22
-
公开(公告)号： EP1750727A2公开(公告)日： 2007-02-14
- 发明人: ANAND, Neel, K. , BLAZEY, Charles, M. , BOWLES, Owen, Joseph , BUSSENIUS, Joerg , CANNE BANNEN, Lynne , CHAN, Diva Sze-Ming , CHEN, Baili , CO, Erick Wang , COSTANZO, Simona , DEFINA, Steven, Charles , DUBENKO, Larisa , FRANZINI, Maurizio , HUANG, Ping , JAMMALAMADAKA, Vasu , KHOURY, Richard George , KIM, Moon, Hwan , KLEIN, Rhett, Ronald , LE, Donna, Tra , MAC, Morrison, B. , PARKS, Jason, Jevious , RICE, Kenneth, D. , NUSS, John M. , TSANG, Tsze , TSUHAKO, Amy Lew , WANG, Yong , XU, Wei
- 申请人： Exelixis, Inc.
- 申请人地址： 170 Harbor Way, P.O. Box 511 South San Francisco, CA 94083-0511 US
- 专利权人： Exelixis, Inc.
- 当前专利权人： Exelixis, Inc.
- 当前专利权人地址： 170 Harbor Way, P.O. Box 511 South San Francisco, CA 94083-0511 US
- 代理机构： Main, Malcolm Charles
- 优先权： US564908 20040423
- 国际公布： WO2005117909 20051215
- 主分类号： A61K31/7076
- IPC分类号： A61K31/7076
摘要：
The present invention relates to compounds of the Formula (I) and (II) wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.
信息查询
IPC分类:
