发明公开
- 专利标题： CHIMERIC GAPPED OLIGOMERIC COMPOSITIONS
- 专利标题（中）： 嵌合低聚物CAP组合物
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申请号： EP04754188.3申请日： 2004-06-03
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公开(公告)号： EP1766052A1公开(公告)日： 2007-03-28
- 发明人: BHAT, Balkrishen , SWAYZE, Eric , ALLERSON, Charles , DANDE, Prasad , PRAKASH, Thazha, P. , GRIFFEY, Richard, H.
- 申请人： ISIS PHARMACEUTICALS, INC.
- 申请人地址： 2292 Faraday Avenue Carlsbad, CA 92008 US
- 专利权人： ISIS PHARMACEUTICALS, INC.
- 当前专利权人： ISIS PHARMACEUTICALS, INC.
- 当前专利权人地址： 2292 Faraday Avenue Carlsbad, CA 92008 US
- 代理机构： Hallybone, Huw George
- 国际公布： WO2005121368 20051222
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; A01N43/04 ; C07H21/04 ; A61K31/07
摘要：
The present invention provides double stranded compositions wherein the first strand comprises three different regions and the second strand is native RNA. Each region has native or modified ribofuranosyl sugar moieties that are different than those of the other two regions. At least a portion of the first oligomeric compound is complementary to and hybridizes to a nucleic acid target. The present invention also provides methods for modulating gene expression using the modified oligomeric compounds and compositions of oligomeric compounds.
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