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公开(公告)号：EP2250595B1
公开(公告)日：2017-06-14
申请号：EP09710859.1
申请日：2009-02-12
申请人： Codexis, Inc.
发明人： FOX, Richard
摘要： The present disclosure relates to methods of rapidly and efficiently searching biologically-related data space to identify a population set maximally diverse and optimized for sets of desired properties. More specifically, the disclosure provides methods of identifying a diverse, evolutionary separated bio-molecules with desired properties from complex bio-molecule libraries. The disclosure additionally provides digital systems and software for performing these methods.
摘要翻译： 本公开涉及快速和有效地搜索生物相关数据空间以识别最大多样化并且针对期望特性组进行优化的群体集合的方法。 更具体地，本公开提供了从复杂生物分子文库中鉴定具有期望特性的多样的，进化分离的生物分子的方法。 本公开另外提供了用于执行这些方法的数字系统和软件。
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公开(公告)号：EP1781661B1
公开(公告)日：2017-06-07
申请号：EP05773384.2
申请日：2005-08-24
申请人： Vantia Limited
发明人： ANDRZEJ, Roman, Batt , BAXTER, Andrew, John , HEENEY, Celine , STOCKLEY, Martin, Lee , ROE, Michael Bryan , HUDSON, Peter , HANDY, Rachel
IPC分类号： C07D487/04 , C07D267/14 , C07D265/36 , C07D215/08 , C07D498/14 , C07D513/14 , A61K31/5517 , A61K31/553 , C07D223/16 , C07D417/10 , C07D231/38 , C07D231/42 , C07D267/16 , C07D333/44 , A61K31/55 , A61K31/495 , A61K31/38 , A61P3/00 , A61P23/00 , A61P35/00
CPC分类号： C07D267/14 , C07D215/08 , C07D223/16 , C07D231/42 , C07D265/36 , C07D267/16 , C07D295/088 , C07D333/44 , C07D413/14 , C07D417/10 , C07D487/04 , C07D498/14 , C07D513/04 , C07D513/14
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公开(公告)号：EP2473196B1
公开(公告)日：2017-05-31
申请号：EP10812718.4
申请日：2010-08-30
IPC分类号： C07K14/52 , A61K9/00 , A61K31/711 , A61K38/00
CPC分类号： A61K38/19 , A61K9/0019 , A61K31/711 , A61K38/00 , A61K48/005 , C07K14/521 , C07K2319/02 , C07K2319/09
摘要： A method of treating a cardiomyopathy in a subject includes administering directly to or expressing locally in a weakened, ischemic, and/or peri-infarct region of myocardial tissue of the subject an amount of SDF-1 effective to cause functional improvement in at least one of the following parameters: left ventricular volume, left ventricular area, left ventricular dimension, cardiac function, 6-minute walk test, or New York Heart Association (NYHA) functional classification.
摘要翻译： 治疗受试者心肌病的方法包括直接给予受试者心肌组织的弱化区域，缺血区域和/或梗塞周围区域或在局部区域表达一定量的SDF-1，其有效引起至少一种 以下参数：左心室容积，左心室面积，左心室尺寸，心脏功能，6分钟步行测试或纽约心脏协会（NYHA）功能分类。
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公开(公告)号：EP2268664B1
公开(公告)日：2017-05-24
申请号：EP08878051.5
申请日：2008-12-08
发明人： LIBUTTI, Steven, K. , KWON, Mijung , TANDLE, Anita
IPC分类号： C07K14/435 , A61K39/00
CPC分类号： C07K14/4703 , A61K35/13 , A61K38/1709 , A61K48/00 , C07K14/47 , C07K16/18 , C07K2317/34 , G01N33/574 , G01N33/57484 , G01N2333/4703 , G01N2800/52
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5.发明授权SYSTEM HAVING DLC CONTACTING FACES, METHOD FOR LUBRICATING THE SYSTEM AND LUBRICATING OIL FOR THE SYSTEM 有权具有DLC接触面的系统，润滑系统和润滑系统润滑油的方法
公开(公告)号：EP1666572B1
公开(公告)日：2017-05-17
申请号：EP04771376.3
申请日：2004-08-06
IPC分类号： C10M169/04 , F01M11/00 , F16H57/04 , C10M101/02 , C10M107/02 , C10M129/00 , C10M133/00 , C10M135/00 , C10M137/00 , C10M159/20
CPC分类号： C10M169/04 , C10M2203/1025 , C10M2205/0206 , C10M2205/173 , C10M2207/00 , C10M2207/026 , C10M2207/262 , C10M2207/289 , C10M2215/04 , C10M2215/064 , C10M2219/046 , C10M2219/068 , C10M2223/02 , C10M2223/042 , C10M2223/045 , C10N2210/02 , C10N2220/022 , C10N2230/04 , C10N2230/06 , C10N2230/08 , C10N2230/43 , C10N2240/10 , C10N2280/00 , Y10T428/30 , C10N2210/06
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6.发明授权METHODS FOR PREPARING SAMPLES FOR NUCLEIC ACID AMPLIFICATION 有权VERFAHREN ZUR HERSTELLUNG VON PROBENFÜRNUKLEINSÄUREAMPLIFIKATION
公开(公告)号：EP2831230B1
公开(公告)日：2017-02-01
申请号：EP13715412.6
申请日：2013-03-28
申请人： Lumora Ltd
CPC分类号： C12Q1/6806 , B01D15/161 , B01D15/3876 , B01L3/502 , B01L2300/0681 , B01L2300/0832 , B01L2400/0442 , C12N15/1006 , C12N15/101 , G01N2030/062 , G01N30/30
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公开(公告)号：EP2397521B1
公开(公告)日：2017-01-25
申请号：EP09840042.7
申请日：2009-11-26
IPC分类号： C08L61/34 , C08G14/073 , C08J5/24 , C08L63/00
CPC分类号： C08G73/0688 , C08G59/4014 , C08K7/02 , C08L63/00 , C08L79/04
摘要： The invention provides a benzoxazine resin composition having excellent resistance to heat and moisture and providing excellent handleability when made into prepreg, and prepreg and a fiber-reinforced composite material prepared from the composition. The composition contains (A) a compound having in its molecule a benzoxazine ring represented by the formula (1), (B) an epoxy resin, (C) a curing agent, and (D) a toughness improver: (R 1 : C1 to C12 chain alkyl group, etc., and H is bonded to at least one of C of the aromatic ring at o- or p-position to the carbon atom to which the oxygen atom is bonded).
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公开(公告)号：EP2217248B1
公开(公告)日：2016-11-30
申请号：EP08844596.0
申请日：2008-10-29
IPC分类号： A61K31/7105 , A61P35/00 , C12N15/11
CPC分类号： C12N15/113 , A61K31/407 , A61K31/44 , A61K31/4745 , A61K31/513 , A61K31/555 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K31/7088 , A61K31/7105 , A61K45/06 , C12N2310/113 , C12N2310/141 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12N2310/3525
摘要： Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Certain miRNAs have been identified as overexpressed in liver cancer, such as, for example, hepatocellular carcinoma, and are thus selected for targeting by modified oligonucleotides. Further, certain miRNAs have been identified as overexpressed in hepatocellular carcinoma cells exposed to dioxin, and are thus selected for targeting by modified oligonucleotides. Antisense inhibition of certain of these miRNAs has been found to inhibit cell proliferation and induce apoptosis.
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9.发明授权ELECTRIC Al-Zr ALLOY PLATING BATH USING ROOM TEMPERATURE MOLTEN SALT BATH AND PLATING METHOD USING THE SAME 有权坏的AL-ZR合金电气隔离在室温下使用液态盐和分离过程熔融这一BADS使用THEREOF
公开(公告)号：EP2130949B8
公开(公告)日：2016-10-12
申请号：EP08711030.0
申请日：2008-02-08
CPC分类号： C25D3/66 , Y10T428/31678
摘要： Disclosed is an electric Al-Zr alloy plating bath containing an aluminum halide (A), one or more compounds (B) selected from the group consisting of N-alkylpyridinium halides, N-alkylimidazolium halides, N,N'-alkylimidazolium halides, N-alkylpyrazolium halides and N,N'-alkylpyrazolium halides, and a zirconium halide (C). The molar ratio between the aluminum halide (A) and the compounds (B) is from 1:1 to 3:1. The electric Al-Zr alloy plating bath further contains an aromatic organic solvent (D), an organic polymer (E) and one or more additives (F) selected from brightening agents.
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10.发明授权
公开(公告)号：EP2130949B1
公开(公告)日：2016-08-31
申请号：EP08711030.0
申请日：2008-02-08
CPC分类号： C25D3/66 , Y10T428/31678
摘要： Disclosed is an electric Al-Zr alloy plating bath containing an aluminum halide (A), one or more compounds (B) selected from the group consisting of N-alkylpyridinium halides, N-alkylimidazolium halides, N,N'-alkylimidazolium halides, N-alkylpyrazolium halides and N,N'-alkylpyrazolium halides, and a zirconium halide (C). The molar ratio between the aluminum halide (A) and the compounds (B) is from 1:1 to 3:1. The electric Al-Zr alloy plating bath further contains an aromatic organic solvent (D), an organic polymer (E) and one or more additives (F) selected from brightening agents.
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