发明公开
- 专利标题： C-MET MODULATORS AND METHOD OF USE
- 专利标题（中）： C-MET调制器和使用方法
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申请号： EP05763620.1申请日： 2005-07-01
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公开(公告)号： EP1773826A2公开(公告)日： 2007-04-18
- 发明人: BANNEN, Lynne Canne , CHAN, Diva Sze-Ming , DALRYMPLE, Lisa Esther , JAMMALAMADAKA, Vasu , KHOURY, Richard George , LEAHY, James William , MAC, Morrison B. , MANN, Grace , MANN, Larry W. , NUSS, John M. , PARKS, Jason Jevious , WANG, Yong , XU, Wei
- 申请人： Exelixis, Inc.
- 申请人地址： 170 Harbor Way, P.O. Box 511 South San Francisco, CA 94083-0511 US
- 专利权人： Exelixis, Inc.
- 当前专利权人： Exelixis, Inc.
- 当前专利权人地址： 170 Harbor Way, P.O. Box 511 South San Francisco, CA 94083-0511 US
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät
- 优先权： US584977P 20040702
- 国际公布： WO2006014325 20060209
- 主分类号： C07D417/04
- IPC分类号： C07D417/04 ; C07D487/04 ; C07D473/06 ; C07D473/10 ; C07D473/22 ; C07D473/24 ; C07D473/30 ; C07D473/34 ; C07D473/38 ; C07D473/40 ; C07D491/04 ; C07D495/04 ; A61K31/52 ; A61K31/522 ; A61K31/519 ; A61K31/437 ; A61K31/4365 ; A61K31/4355 ; A61P35/00
摘要：
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides appropriately functionalized 5,6-fused bicyclics which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, and flt-3, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
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