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78 条记录 (耗时 0.015 秒)

    THIOXANTHINE DERIVATIVES AS MYELOPEROXIDASE INHIBITORS
    1.
    发明授权
    THIOXANTHINE DERIVATIVES AS MYELOPEROXIDASE INHIBITORS 有权
    硫代吗啉酸甲羟孕酮

    公开(公告)号：EP1499613B1

    公开(公告)日：2011-10-19

    申请号：EP03721211.5

    申请日：2003-04-15

    申请人： AstraZeneca AB

    发明人： HANSON, Sverker ,  NORDVALL, Gunnar ,  TIDEN, Anna-Karin

    IPC分类号： C07D473/20 ,  C07D473/22 ,  A61K31/52 ,  A61K31/522 ,  A61P25/28 ,  A61P35/00

    CPC分类号： A61K31/522 ,  C07D473/22

    摘要： There is disclosed the use of a compound of formula (Ia) or (Ib)wherein R1, R2, R3, R4, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of the enzyme myeloperoxidase (MPO) is beneficial. Certain novel compounds of formula (Ia) or (Ib) and pharmaceutically acceptable salts thereof are disclosed, together with processes for their preparation. The compounds of formulae (Ia) and (Ib) are MPO inhibitors and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders.

    THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO
    3.
    发明公开
    THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO 审中-公开
    硫蒽衍生物及其作为MPO抑制剂的用途

    公开(公告)号：EP2010534A1

    公开(公告)日：2009-01-07

    申请号：EP07748014.3

    申请日：2007-04-12

    申请人： AstraZeneca AB

    发明人： PIVONKA, Donald ,  TIDÉN, Anna-Karin ,  VIKLUND, Jenny

    IPC分类号： C07D473/22 ,  A61K31/522 ,  A61P11/08 ,  A61P25/16 ,  A61P9/10 ,  A61K31/52 ,  C07D473/20

    CPC分类号： C07D473/20 ,  C07D473/22

    摘要： There are disclosed novel compounds of Formula (I) wherein R1, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders, cardio- and cerebrovascular atherosclerotic disorders and peripheral artery disease and respiratory disorders.

    摘要翻译： 公开了式（I）的新化合物及其药学上可接受的盐，其中R 1，X和Y如说明书中所定义; 以及它们的制备方法，含有它们的组合物以及它们在治疗中的用途。 这些化合物是MPO酶的抑制剂，因此特别适用于治疗或预防神经炎性疾病，心血管和脑血管动脉粥样硬化疾病以及外周动脉疾病和呼吸系统疾病。

    THIOXANTHINE DERIVATIVES AS MYELOPEROXIDASE INHIBITORS
    4.
    发明公开
    THIOXANTHINE DERIVATIVES AS MYELOPEROXIDASE INHIBITORS 有权
    硫代黄嘌呤衍生物作为myveloerOXIDase抑制剂

    公开(公告)号：EP1499613A1

    公开(公告)日：2005-01-26

    申请号：EP03721211.5

    申请日：2003-04-15

    申请人： AstraZeneca AB

    发明人： HANSON, Sverker ,  NORDVALL, Gunnar ,  TIDEN, Anna-Karin

    IPC分类号： C07D473/20 ,  C07D473/22 ,  A61K31/52 ,  A61K31/522 ,  A61P25/28 ,  A61P35/00

    CPC分类号： A61K31/522 ,  C07D473/22

    摘要： There is disclosed the use of a compound of formula (Ia) or (Ib)wherein R1, R2, R3, R4, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of the enzyme myeloperoxidase (MPO) is beneficial. Certain novel compounds of formula (Ia) or (Ib) and pharmaceutically acceptable salts thereof are disclosed, together with processes for their preparation. The compounds of formulae (Ia) and (Ib) are MPO inhibitors and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders.

    摘要翻译： 公开了其中R 1，R 2，R 3，R 4，X和Y如说明书中所定义的式（Ia）或（Ib）化合物及其药学上可接受的盐在制备药物中的用途， 治疗或预防其中抑制髓过氧化物酶（MPO）有益的疾病或病症。 公开了式（Ia）或（Ib）的某些新型化合物及其药学上可接受的盐以及它们的制备方法。 式（Ia）和（Ib）的化合物是MPO抑制剂，并因此特别用于治疗或预防神经炎性疾病。

    Xanthine derivatives, a process for their preparation and their use in pharmaceutical compositions
    10.
    发明公开
    Xanthine derivatives, a process for their preparation and their use in pharmaceutical compositions 失效
    黄嘌呤衍生物，其制备方法及其在药物组合物中的用途

    公开(公告)号：EP0018136A1

    公开(公告)日：1980-10-29

    申请号：EP80301053.7

    申请日：1980-04-02

    申请人： BEECHAM - WUELFING GmbH & Co. KG

    发明人： Goring, Joachim Ewald

    IPC分类号： C07D473/22 ,  C07D473/20 ,  A61K31/52

    CPC分类号： C07D473/22 ,  C07D473/20

    摘要： Compounds of the formula (II):
    wherein:

    X is sulphur and Y is oxygen or sulphur;
    R, is an alkyl group of up to 6 carbon atoms;
    R 2 is an alkyl group of up to 6 carbon atoms; and
    n is 1; or
    X is oxygen and Y is sulphur; one of R, and R 2 is an alkyl group of up to 6 carbon atoms and the other is an alkyl group of 2 to 6 carbon atoms; and
    n is 1 or 2, having useful pharmacological activity, pro-drugs therefor, a process for their preparation, pharmaceutical compositions containing said compounds or pro-drugs, and intermediate in their preparation of the compounds.

    摘要翻译： 式（II）的化合物：其中：X是硫并且Y是氧或硫; R 1是至多6个碳原子的烷基; R2是至多6个碳原子的烷基; 并且n是1; 或X是氧且Y是硫; R 1和R 2中的一个是具有至多6个碳原子的烷基，另一个是具有2至6个碳原子的烷基; 并且n是1或2，具有有用的药理学活性，其前体药物，其制备方法，含有所述化合物或前体药物的药物组合物，以及它们在制备所述化合物中的中间体。