发明公开
EP1773861A2 MALATE SYNTHASE REGULATORY SEQUENCES FOR HETEROLOGOUS GENE EXPRESSION IN PICHIA
审中-公开
MALATSYNTHASEREGULATORSEQUENZEN FOR在毕赤异源基因表达
- 专利标题： MALATE SYNTHASE REGULATORY SEQUENCES FOR HETEROLOGOUS GENE EXPRESSION IN PICHIA
- 专利标题（中）： MALATSYNTHASEREGULATORSEQUENZEN FOR在毕赤异源基因表达
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申请号： EP05805033.7申请日： 2005-07-22
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公开(公告)号： EP1773861A2公开(公告)日： 2007-04-18
- 发明人: CHOI, Byung-Kwon
- 申请人： GlycoFi, Inc.
- 申请人地址： 21 Lafayette Street, Suite 200 Lebanon, New Hampshire 03766 US
- 专利权人： GlycoFi, Inc.
- 当前专利权人： GlycoFi, Inc.
- 当前专利权人地址： 21 Lafayette Street, Suite 200 Lebanon, New Hampshire 03766 US
- 代理机构： Horgan, James Michael Frederic
- 优先权： US590756P 20040722
- 国际公布： WO2006024972 20060309
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C12N1/15 ; C12N15/00 ; C12N15/81
摘要：
The present invention relates to the isolation of DNA regulatory regions of the malate synthase 1 gene (MLS1) from the yeast, Pichia pastoris. The present invention further relates to the expression of heterologous proteins which have been introduced into a P. pastoris host cell and can be expressed under the regulation of the MLS1 5' regulatory promoter and MLS1 3'regulatory terminator regions. The MLS1 promoter is repressed in media containing glucose and derepressed under glucose starvation conditions or when acetate is present.
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