发明公开
EP1778649A1 A PROCESS FOR PRODUCING PURE FORM OF 2-METHYL-4-(4-METHYL-1-PIPERAZINYL)-10H-THIENO[2,3-b][1,5]BENZODIAZEPINE
审中-公开
PROCESS FOR 2-甲基-4-（4-甲基-1-哌嗪基）纯的形式的制备-10H-噻吩并[2,3-B] [1,5]苯并二氮杂
- 专利标题： A PROCESS FOR PRODUCING PURE FORM OF 2-METHYL-4-(4-METHYL-1-PIPERAZINYL)-10H-THIENO[2,3-b][1,5]BENZODIAZEPINE
- 专利标题（中）： PROCESS FOR 2-甲基-4-（4-甲基-1-哌嗪基）纯的形式的制备-10H-噻吩并[2,3-B] [1,5]苯并二氮杂
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申请号： EP04745138.0申请日： 2004-07-14
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公开(公告)号： EP1778649A1公开(公告)日： 2007-05-02
- 发明人: SHASTRI, Jwalant Ashesh, Jubilant Organosys Ltd. , BHATNAGAR, Akshat, Jubilant Organosys Ltd. , THAPER, Rajesh Kumar, Jubilant Organosys Ltd. , DUBEY, Sushil Kumar, Jubilant Organosys Ltd.
- 申请人： Jubilant Organosys Limited
- 申请人地址： 1A, Sector 16A, Institutional Area Noida 201 301, Uttar Pradesh IN
- 专利权人： Jubilant Organosys Limited
- 当前专利权人： Jubilant Organosys Limited
- 当前专利权人地址： 1A, Sector 16A, Institutional Area Noida 201 301, Uttar Pradesh IN
- 代理机构： Marlow, Nicholas Simon
- 国际公布： WO2006006180 20060119
- 主分类号： C07D243/10
- IPC分类号： C07D243/10
摘要：
Disclosed is a process for producing pure form of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine. The process comprises of reacting 2-(2-aminoanilino)-5-methylthiophene-3-carbonitrile with N-methyl piperazine in conjunction with N-methylpiperazine acid salt, to produce 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine. Also disclosed is a process for obtaining the Polymorphic Form I of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine by crystallizing the crude 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine in a mixture of solvents.
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