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公开(公告)号：EP1891081B1
公开(公告)日：2014-08-20
申请号：EP05759257.8
申请日：2005-06-13
发明人： PANDEY, Satish, Chandra Jubilant Organosys Ltd. , HAIDER, Hussain Jubilant Organsys Ltd. , SAXENA, Sudhanshu Jubilant Organsys Ltd. , SINGH, Manoj, Kumar Jubilant Organsys Ltd. , THAPER, Rajesh, Kumar Jubilant Organsys Ltd. , DUBEY, Sushil, Kumar Jubilant Organsys Ltd.
IPC分类号： C07F9/38 , C07F9/28 , C07F9/58 , C07F9/6506 , C07F9/6561
CPC分类号： C07F9/3873 , C07F9/386 , C07F9/582 , C07F9/65061 , C07F9/6561
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2.发明公开PROCESS FOR PRODUCING 2-(N-BUTYL)-3-[[2'-(TETRAZOL-5-YL)BIPHENYL- 4-YL]METHYL]-1,3-DIAZASPIRO[4.4]NON-1-EN-4-ONE 审中-公开用于生产2-（正丁基）-3 - [[2“ - （四唑-5-基）联苯-4-基]甲基] -1,3-二氮杂螺[4.4]壬-1-烯-4- -ON
公开(公告)号：EP1951714A1
公开(公告)日：2008-08-06
申请号：EP06780546.5
申请日：2006-07-27
发明人： KISHORE, Charugundia, Jubilant Organosys Ltd, 56 , BANDI, Vinod, Vishwanath, Jubilant Organosys Ltd, , MURALI, Rajappa, Jubilant Organosys Ltd, 56 , SATISH, M., A., Jubilant Organosys Ltd, 56 , MANJUNATHA, Sulur, G., Jubilant Organosys Ltd, 56
IPC分类号： C07D403/10 , C07D235/02
CPC分类号： C07D235/02 , C07D257/04 , C07D403/10
摘要： Disclosed herein a process for producing 2- (n-butyl) -3- [ [2’ - (tetrazol-5-yl)biphenyl-4-yl]methyl] -1,3 -diazaspiro [4.4] non-l-en-4 -one of formula (I) in pure form by using selective solvent system and cost efficient raw materials and reagents.
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公开(公告)号：EP1648869A1
公开(公告)日：2006-04-26
申请号：EP03817293.8
申请日：2003-12-31
发明人： KUMAR, Rajiv , JOSHI, Praphulla Narahar , CHAPEKAR, Gopal Moreshwar , NIPHADKAR, Prashant Suresh , AGARWAL, Ashutosh, Jubilant Organosys Limited , VERMA, Pradeep Kumar, Jubilant Organosys Limited , SINGH, Kumar Samir, Jubilant Organosys Limited
IPC分类号： C07D213/08 , C07D213/09
CPC分类号： C07D213/08 , C07D213/10
摘要： An process for the preparation of pyridine and/or picolines is disclosed. The process comprises contacting a mixture of carbonyl compound with ammonia in the presence of surface-passivated titanium-silicate catalyst in gas phas at a temperature ranging between 300-500°C, at gas space velocity in the range of 300 to 3000 h-1 and at a pressure ranging between 1 to 10 atmosphere, condensing and separating the products by conventional methods and if desired, further purifiying the product using well known conventional methods.
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4.发明授权A RUMEN BYPASS COMPOSITION CONTAINING A BIOACTIVE SUBSTANCE AND A METHOD FOR ITS PREPARATION 有权PANSE渗透成分含生物活性物质及过程及其
公开(公告)号：EP1381285B1
公开(公告)日：2005-09-21
申请号：EP02717030.7
申请日：2002-04-08
CPC分类号： A23K50/10 , A23K20/142 , A23K20/174 , A23K40/35
摘要： A rumen bypass composition containing a bioactive substance capable of releasing said bioactive substance into the post rumen portion of the digestive system of a ruminant without introducing into the rumen of the digestive system is disclosed. The composition is in the form of beadlets and comprises of a core consisting of a bioactive substance; a hydrophobic coating material, which completely encapsulates the core to avoid interaction within the rumen of a ruminant; an adjuvant hydrophobic in nature having a melting range 50-80 DEG C added to the coating material to improve thermal resistance wherein said beadlets have a size of about 2 to 8 mm, the amount of said bioactive material being in the range of 30 to 60% of the weight of the beadlet, the amount of said coating material is in the range of from 40 to 80% by weight and the amount of said adjuvant being in the range of from 5 to 50% based on the weight of said coating material. The method preparation comprises of mixing an aqueous bioactive substance with a coating material, heating the mixture under constant stirring at a temperature in the range of 55 to 80 DEG C to produce a molten mass, allowing drops of said molten mass to fall from a height through precooled air over a cold surface to obtain said composition in the form of beadlets.
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5.发明授权A process for producing pure form form of 2-Methyl-4-(4-Methyl-1-Piperazinyl)-10h-thieno[2,3-B][1,5] benzodiazepine 有权一种用于2-甲基-4-（4-甲基-1-哌嗪基）的纯形式的制备方法-10H-噻吩并[2,3-B] [1,5]苯并二氮杂
公开(公告)号：EP2264016B1
公开(公告)日：2013-05-01
申请号：EP10075309.4
申请日：2004-07-14
IPC分类号： C07D243/10 , C07D333/38 , C07D495/04
CPC分类号： C07D495/04 , C07D243/10 , C07D333/38
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6.发明公开STABILIZED SUSTAINED RELEASE COMPOSITION OF BUPROPION HYDROCHLORIDE AND PROCESS FOR PREPARING THE SAME 审中-公开安非他酮盐酸盐稳定的组合物缓释及其制备方法
公开(公告)号：EP2229053A2
公开(公告)日：2010-09-22
申请号：EP08870575.1
申请日：2008-11-19
IPC分类号： A01N33/02 , A61K31/135
CPC分类号： A61K31/137 , A61K9/2027 , A61K9/2866
摘要： Disclosed herein is a stabilized sustained release pharmaceutical composition of bupropion hydrochloride and process for preparing the same, wherein said pharmaceutical composition comprising therapeutically effective amount of uncoated fine bupropion hydrochloride and pharmaceutically acceptable adjuvants, and wherein the composition is free of an acidic stabilizer and contains less than about 0.3% by weight of m-chlorobenzoic acid.
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公开(公告)号：EP1786765B1
公开(公告)日：2009-09-02
申请号：EP04770705.4
申请日：2004-09-08
发明人： SINGH, Govind , BHADWAL, Paramvir , JAISWAL, Sanjay , PANCHASARA, Dinesh, R , THAPER, Rajesh, Kumar , DUBEY, Sushil, Kumar , KHANNA, Jag, Mohan
IPC分类号： C07C309/30
CPC分类号： C07D309/30
摘要： The present invention relates to an improved and industrial friendly process for lactonization to produce compound of the Formula [I], from compound of the Formula [II] in presence of an inorganic compound as a suitable lactonizing agent, preferably alkali metal hydrogen sulfate, and crystallizing the obtained lactone product in a solvent; or treating compound of the Formula [II] in the presence of an inorganic compound preferably alkali metal hydrogen sulfate using phase transfer catalyst in heterogeneous phase followed by crystallizing the obtained lactone product in a solvent.
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8.发明公开
公开(公告)号：EP1877394A1
公开(公告)日：2008-01-16
申请号：EP06728421.6
申请日：2006-04-04
发明人： DAS, Prasenjit Prafulla , GOANKAR, Santosh Laxman , MANJUNATHA, Sulur, G. , NARAHARI BABU, Ambati
IPC分类号： C07D307/87
CPC分类号： C07D307/87
摘要： The present invention relates to Formula (I), a process for the preparation of highly pure Escitalopram or its acid addition salts which comprises: a) reacting racemic diol or its ester derivative (III) with an optically active acid and at least one solvent to get enantiomerically pure diastereomer (IIIA); b) separating the enantiomerically pure diastereomer (IIIA) from its optically active acid salt by treating it with base and followed by stereo selective cyclization; c) separating the Escitalopram base.
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9.发明公开PROCESS FOR PREPARING A PURE POLYMORPHIC FORM OF 3-PYRIDYL-1-HYDROXYETHYLIDINE-1,1-BISPHOSPHONIC ACID SODIUM SALT 审中-公开法用于生产3-吡啶基-1- hydroxyethylidine -1,1-二膦酸钠盐纯净的多晶
公开(公告)号：EP1828214A1
公开(公告)日：2007-09-05
申请号：EP04799395.1
申请日：2004-11-09
发明人： PANDEY, Satish Chandra, Jubilant Organosys Ltd. , RAM, Khushi, Jubilant Organosys Ltd , SINGH, Manoj Kumar, Jubilant Organosys Ltd , THAPER, Rajesh Kumar, Jubilant Organosys Ltd. , DUBEY, Sushil Kumar, Jubilant Organosys Ltd.
IPC分类号： C07F9/38
CPC分类号： C07F9/582
摘要： This process in general relates to the novel process for preparing polymorphic forms of 3-pyridyl-l-hydroxyethylidine-1,1-bisphosphonic acid sodium salt (Risedronate Sodium) in particular risedronate Form A and B employing a solvent system in an appropriate ratio. An improved process for preparation of risedronic acid is also disclosed in the present invention.
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10.发明公开A PROCESS FOR PRODUCING PURE FORM OF 2-METHYL-4-(4-METHYL-1-PIPERAZINYL)-10H-THIENO[2,3-b][1,5]BENZODIAZEPINE 审中-公开PROCESS FOR 2-甲基-4-（4-甲基-1-哌嗪基）纯的形式的制备-10H-噻吩并[2,3-B] [1,5]苯并二氮杂
公开(公告)号：EP1778649A1
公开(公告)日：2007-05-02
申请号：EP04745138.0
申请日：2004-07-14
发明人： SHASTRI, Jwalant Ashesh, Jubilant Organosys Ltd. , BHATNAGAR, Akshat, Jubilant Organosys Ltd. , THAPER, Rajesh Kumar, Jubilant Organosys Ltd. , DUBEY, Sushil Kumar, Jubilant Organosys Ltd.
IPC分类号： C07D243/10
CPC分类号： C07D495/04 , C07D243/10 , C07D333/38
摘要： Disclosed is a process for producing pure form of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine. The process comprises of reacting 2-(2-aminoanilino)-5-methylthiophene-3-carbonitrile with N-methyl piperazine in conjunction with N-methylpiperazine acid salt, to produce 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine. Also disclosed is a process for obtaining the Polymorphic Form I of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine by crystallizing the crude 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine in a mixture of solvents.
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