发明公开
- 专利标题: Vanilloid receptor ligands and their use in treatments
- 专利标题(中): 香草素受体配体及其在治疗中的用途
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申请号: EP07000804.0申请日: 2004-09-30
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公开(公告)号: EP1780211A2公开(公告)日: 2007-05-02
- 发明人: Chen, Ning , Nixey, Thomas , Norman, Mark H.
- 申请人: Amgen Inc.
- 申请人地址: One Amgen Center Drive Thousand Oaks, CA 91320-1799 US
- 专利权人: Amgen Inc.
- 当前专利权人: Amgen Inc.
- 当前专利权人地址: One Amgen Center Drive Thousand Oaks, CA 91320-1799 US
- 代理机构: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät
- 优先权: US507863P 20030930
- 主分类号: C07D417/12
- IPC分类号: C07D417/12 ; C07D401/12 ; C07D405/12
摘要:
Compounds having the general structure formula (I)
and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
公开/授权文献
- EP1780211A3 Vanilloid receptor ligands and their use in treatments 公开/授权日:2007-06-06
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