公开(公告)号：EP2270006A1

公开(公告)日：2011-01-05

申请号：EP10008426.8

申请日：2003-08-08

申请人： Amgen, Inc

发明人： Chakrabarti, Partha P. ,  Chen, Ning ,  Doherty, Elizabeth M. ,  Dominguez, Celia ,  Falsey, James Richard ,  Fotsh, Christopher H. ,  Hulme, Christopher ,  Katon, Jodie ,  Nixey, Thomas ,  Norman, Mark H. ,  Ognyanov, Vassil I. ,  Pettus, Liping H. ,  Rzasa, Robert Michael ,  Stec, Markian ,  Wang, Hui-Ling ,  Zhu, Jiawang

IPC分类号： C07D417/12 ,  C07D401/12 ,  A61K31/501 ,  A61P29/00

CPC分类号： C07D231/40 ,  C07D209/08 ,  C07D209/12 ,  C07D209/42 ,  C07D209/48 ,  C07D213/26 ,  C07D213/643 ,  C07D213/74 ,  C07D213/75 ,  C07D215/227 ,  C07D215/38 ,  C07D217/04 ,  C07D231/56 ,  C07D233/38 ,  C07D239/42 ,  C07D239/90 ,  C07D241/42 ,  C07D263/56 ,  C07D265/36 ,  C07D277/62 ,  C07D277/82 ,  C07D307/79 ,  C07D319/20 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

or any pharmaceutically-acceptable salt thereof, wherein:
J is O or S;
X is = C(R 2 );
Y is N;

摘要翻译： 具有一般结构和含有它们的组合物的化合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性 疾病，骨关节炎，炎症性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病痛， 咳嗽痛，交感神经保持疼痛，交感综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道内脏运动紊乱，泌尿生殖道，胃肠道或血管区，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风，一般胃肠道疾病， G 腹部溃疡，十二指肠溃疡，腹泻，坏死因子诱发的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。 或其任何药学上可接受的盐，其中：J为O或S; X = C（R 2）; Y是N;

公开(公告)号：EP1775295A1

公开(公告)日：2007-04-18

申请号：EP07000807.3

申请日：2004-09-30

申请人： Amgen Inc.

发明人： Chen, Ning ,  Nixey, Thomas ,  Norman, Mark H.

IPC分类号： C07D417/12 ,  C07D401/12 ,  C07D405/12

CPC分类号： C07D417/12 ,  C07D401/12 ,  C07D405/12

摘要： Compounds having the general structure formula (I)

and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, bums, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

摘要翻译： 具有通式结构式（I）的化合物和含有它们的组合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般性头痛，偏头痛，丛集性头痛，混合血管和非血管性综合征，紧张性头痛，一般炎症 ，关节炎，风湿性疾病，骨关节炎，炎症性肠病，炎症性眼病，炎性或不稳定性膀胱病症，牛皮癣，具有炎性成分的皮肤病，慢性炎症，炎症性疼痛和相关的痛觉过敏和异常性疼痛，神经性疼痛和相关的痛觉过敏和异常性疼痛， 糖尿病性神经病疼痛，灼痛，交感神经维持性疼痛，传入神经缺失综合症，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道内脏运动障碍，泌尿生殖器，胃肠或血管区域，伤口，烧伤，过敏性皮肤反应，瘙痒症， 一般胃肠d 胃溃疡，十二指肠溃疡，腹泻，由坏死物质诱导的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

公开(公告)号：EP2114898A2

公开(公告)日：2009-11-11

申请号：EP08725619.4

申请日：2008-02-15

申请人： Amgen Inc.

发明人： Albrecht, Brian K. ,  Bellon, Steven ,  Booker, Shon ,  Cheng, Alan C. ,  D'amico, Derin ,  D'angelo, Noel ,  Harmange, Jean-christophe ,  Kim, Tae-seong ,  Liu, Longbin ,  Norman, Mark H. ,  Siegmund, Aaron C. ,  Stec, Markian ,  Xi, Ning ,  Yang, Kevin

IPC分类号： C07D237/16 ,  A61K31/4709 ,  A61K31/4545 ,  A61K31/444 ,  A61K31/501 ,  A61K31/497 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04

CPC分类号： C07D237/16 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04

摘要： Selected compounds defined by Formula I, II, III, IV or V are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases.

公开(公告)号：EP1780211A3

公开(公告)日：2007-06-06

申请号：EP07000804.0

申请日：2004-09-30

申请人： Amgen Inc.

发明人： Chen, Ning ,  Nixey, Thomas ,  Norman, Mark H.

IPC分类号： C07D417/12 ,  C07D401/12 ,  C07D405/12

CPC分类号： C07D417/12 ,  C07D401/12 ,  C07D405/12

摘要： Compounds having the general structure formula (I)

and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

公开(公告)号：EP1818333A1

公开(公告)日：2007-08-15

申请号：EP07009856.1

申请日：2004-02-09

申请人： Amgen Inc.

发明人： Doherty, Elizabeth M. ,  Fotsch, Christopher H. ,  Han, Nianhe ,  Hungate, Randall W. ,  Liu, Qingyian ,  Norman, Mark H. ,  Xi, Ning ,  Xu, Shimin

IPC分类号： C07D417/04 ,  C07D417/12 ,  C07D403/04 ,  C07D277/20 ,  C07D233/66 ,  C07D263/34 ,  A61P29/00 ,  A61K41/00

CPC分类号： C07D233/90 ,  C07D263/34 ,  C07D277/56 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

摘要： Compounds having the general structure

and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

摘要翻译： 具有一般结构和含有它们的组合物的化合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性 疾病，骨关节炎，炎症性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病痛， 咳嗽痛，交感神经保持疼痛，交感综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道内脏运动紊乱，泌尿生殖道，胃肠道或血管区，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风，一般胃肠道疾病， G 腹部溃疡，十二指肠溃疡，腹泻，坏死因子诱发的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

公开(公告)号：EP3093289A1

公开(公告)日：2016-11-16

申请号：EP16175883.4

申请日：2007-07-13

申请人： Amgen, Inc

发明人： Albrecht, Brian ,  Bauer, David ,  Bellon, Steven ,  Bode, Christiane M. ,  Booker, Shon ,  Boezio, Alessandro ,  Choquette, Deborah ,  D'Amico, Derin C. ,  Harmange, Jean Christophe ,  Hirai, Satoko ,  Hungate, Randall W. ,  Kim, Tae-Seong ,  Lewis, Richard T. ,  Longbin, Liu ,  Lohman, Julia ,  Norman, Mark H. ,  Potashman, Michele ,  Siegmund, Aaron C. ,  Springer, Stephanie ,  Xi, Ning ,  Yang, Kevin ,  Stec, Markian

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D471/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：EP1780211A2

公开(公告)日：2007-05-02

申请号：EP07000804.0

申请日：2004-09-30

申请人： Amgen Inc.

发明人： Chen, Ning ,  Nixey, Thomas ,  Norman, Mark H.

IPC分类号： C07D417/12 ,  C07D401/12 ,  C07D405/12

CPC分类号： C07D417/12 ,  C07D401/12 ,  C07D405/12

摘要： Compounds having the general structure formula (I)

and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

摘要翻译： 具有通式结构式（I）的化合物和含有它们的组合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般性头痛，偏头痛，丛集性头痛，混合血管和非血管性综合征，紧张性头痛，一般炎症 ，关节炎，风湿性疾病，骨关节炎，炎症性肠病，炎症性眼病，炎性或不稳定性膀胱病症，牛皮癣，具有炎性成分的皮肤病，慢性炎症，炎症性疼痛和相关的痛觉过敏和异常性疼痛，神经性疼痛和相关的痛觉过敏和异常性疼痛， 糖尿病性神经病疼痛，灼痛，交感神经维持性疼痛，神经传导障碍综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道内脏动力障碍，泌尿生殖器，胃肠或血管区域，伤口，烧伤，过敏性皮肤反应，瘙痒症， 一般胃肠道 胃溃疡，十二指肠溃疡，腹泻，由坏死物质诱导的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。