发明公开
EP1792613A2 Dicationic compounds which selectively recognize G-quadruplex DNA
审中-公开
Dicationische Verbindungen死于selektiv G-Quadruplex-DNA erkennen
- 专利标题： Dicationic compounds which selectively recognize G-quadruplex DNA
- 专利标题（中）： Dicationische Verbindungen死于selektiv G-Quadruplex-DNA erkennen
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申请号： EP06118366.1申请日： 2006-08-03
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公开(公告)号： EP1792613A2公开(公告)日： 2007-06-06
- 发明人: Tidwell, Richard R. , Boykin, David W. , Ismail, Mohamed A. , Wilson, W. David , White, Elizabeth W. , Kumar, Arvind , Nanjunda, Rupesh
- 申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
- 申请人地址： 308 Bynum Hall, Chapel Hill, NC 27599-4105 US
- 专利权人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL,GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
- 当前专利权人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL,GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
- 当前专利权人地址： 308 Bynum Hall, Chapel Hill, NC 27599-4105 US
- 代理机构： Behnisch, Werner
- 优先权： US741689P 20051202
- 主分类号： A61K31/33
- IPC分类号： A61K31/33 ; A61K31/341 ; A61K31/381 ; A61K31/4164 ; A61K31/4184 ; A61K31/443 ; A61P33/02 ; A61P35/00 ; C07D307/68 ; C07D329/00 ; C07D405/14 ; C07D421/14
摘要：
Dicationic compounds that are highly selective for binding G-quadruplex DNA are described. Several compounds exhibit groove binding toward G-quadruplex DNA and in vitro and in vivo activity versus Trypanosoma brucei rhodesiense. The compounds represent novel drugs for the treatment of cancer, malaria, leishmania, and trypanosomiasis.
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