发明公开
EP1797104A1 DERIVATIVES OF [2-(8,9-DIOXO-2,6-DIAZABICYCLO[5.2.0]NON-1(7)-EN-2-YL)ALKYL]PHOSPHONIC ACID AND METHOD OF MAKING THEM 有权
导数的[2-(8,9-二氧代-2,6-二氮杂双环[5.2.0]壬-1(7) - 烯-2-基)烷基]用于制造膦AND METHOD

  • 专利标题: DERIVATIVES OF [2-(8,9-DIOXO-2,6-DIAZABICYCLO[5.2.0]NON-1(7)-EN-2-YL)ALKYL]PHOSPHONIC ACID AND METHOD OF MAKING THEM
  • 专利标题(中): 导数的[2-(8,9-二氧代-2,6-二氮杂双环[5.2.0]壬-1(7) - 烯-2-基)烷基]用于制造膦AND METHOD
  • 申请号: EP05803939.7
    申请日: 2005-10-06
  • 公开(公告)号: EP1797104A1
    公开(公告)日: 2007-06-20
  • 发明人: BAUDY, Reinhardt, Richard
  • 申请人: Wyeth
  • 申请人地址: Five Giralda Farms Madison, NJ 07940-0874 US
  • 专利权人: Wyeth
  • 当前专利权人: Wyeth
  • 当前专利权人地址: Five Giralda Farms Madison, NJ 07940-0874 US
  • 代理机构: Wileman, David Francis
  • 优先权: US617023P 20041008
  • 国际公布: WO2006041975 20060420
  • 主分类号: C07F9/645
  • IPC分类号: C07F9/645 A61K31/675 A61P25/02
DERIVATIVES OF [2-(8,9-DIOXO-2,6-DIAZABICYCLO[5.2.0]NON-1(7)-EN-2-YL)ALKYL]PHOSPHONIC ACID AND METHOD OF MAKING THEM
摘要:
Compounds of formula (I) or pharmaceutically acceptable salts thereof are provided (Formula I): wherein: A is alkylenyl of 1 to 4 carbon atoms, or alkenylenyl of 2 to 4 carbon atoms; R1 and R2 are, independently, hydrogen or a C5 to C7 aryl optionally substituted with 1 to 2 substituents, independently, selected from the group consisting of -C(O)R3, halogen, cyano, nitro, hydroxyl, C1-C6 alkyl, and C1-C6 alkoxy, with the proviso that at least one of R1, and R2 is not hydrogen; R3 is, independently, hydrogen, -OR4, alkyl, aryl, or heteroaryl; R4 is hydrogen, alkyl, aryl, or heteroaryl; R5 and R6 are, independently, hydrogen, alkyl, hydroxyl, alkoxy, or C5 to C7 aryl; wherein any R3 to R6 group having an aryl or heteroaryl moiety can optionally be substituted on the aryl or heteroaryl moiety with 1 to about 5 substituents, independently, selected from the group consisting of halogen, cyano, nitro, hydroxyl, C1-C6 alkyl, and C1-C6 alkoxy. Methods of making these compounds as well as methods using the compounds for treating a variety of conditions are also disclosed.
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