发明公开
EP1802749A2 KASPP (LRRK2) GENE, ITS PRODUCTION AND USE FOR THE DETECTION AND TREATMENT OF NEURODEGENERATIVE DISORDERS
有权
KASPP（LRRK2）GEN，ITS检测和治疗神经退行性疾病的生产和使用
- 专利标题： KASPP (LRRK2) GENE, ITS PRODUCTION AND USE FOR THE DETECTION AND TREATMENT OF NEURODEGENERATIVE DISORDERS
- 专利标题（中）： KASPP（LRRK2）GEN，ITS检测和治疗神经退行性疾病的生产和使用
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申请号： EP05797320.8申请日： 2005-09-27
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公开(公告)号： EP1802749A2公开(公告)日： 2007-07-04
- 发明人: MEITINGER, Thomas , STROM, Tim, Matthias , BISKUP, Saskia , UEFFING, Marius , KREMMER, Elisabeth , GLOECKNER, Christian, J. , GASSER, Thomas , LEITNER, Petra , ASMUS, Friedrich , PATENGE, Nadja , ZIMPRICH, Alexander , FARRER, Matthew, J. , KACHERGUS, Jennifer, M. , LINCOLN, Sara, J. , HULIHAN, Mary, M. , WSZOLEK, Zibigniew , UITTI, Ryan
- 申请人： GSF-FORSCHUNGSZENTRUM FÜR UMWELT UND GESUNDHEIT, GMBH , Eberhard Karls Universität Tübingen , Mayo Clinic
- 申请人地址： Ingolstädter Landstrasse 1 85764 Neuherberg DE
- 专利权人： GSF-FORSCHUNGSZENTRUM FÜR UMWELT UND GESUNDHEIT, GMBH,Eberhard Karls Universität Tübingen,Mayo Clinic
- 当前专利权人： GSF-FORSCHUNGSZENTRUM FÜR UMWELT UND GESUNDHEIT, GMBH,Eberhard Karls Universität Tübingen,Mayo Clinic
- 当前专利权人地址： Ingolstädter Landstrasse 1 85764 Neuherberg DE
- 代理机构： Bösl, Raphael Konrad
- 优先权： US620893P 20041021; US621169P 20041022
- 国际公布： WO2006045392 20060504
- 主分类号： C12N9/12
- IPC分类号： C12N9/12
摘要：
The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.
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