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公开(公告)号：EP4444871A1
公开(公告)日：2024-10-16
申请号：EP22835228.2
申请日：2022-12-07
发明人： ACHBERGER, Kevin , LIEBAU, Stefan
IPC分类号： C12N5/0793 , C12N5/00 , A61L27/36 , B33Y70/00
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公开(公告)号：EP4426311A1
公开(公告)日：2024-09-11
申请号：EP22813502.6
申请日：2022-11-02
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公开(公告)号：EP4415740A1
公开(公告)日：2024-08-21
申请号：EP22803177.9
申请日：2022-10-12
发明人： WATZER, Björn , FORCHHAMMER, Karl
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公开(公告)号：EP4374870A1
公开(公告)日：2024-05-29
申请号：EP22208908.8
申请日：2022-11-22
CPC分类号： C07K14/78 , A61K38/39 , C12N2800/2220130101 , C12N15/85 , A61K48/005 , A61K48/0066 , A61K48/0025
摘要： The present invention relates to oligonucleotides for induction of elastin de-novo synthesis in mammals, a method of treatment of diseases and medical conditions associated with insufficient tissue elasticity, use of the oligonucleotide in such treatment, as well as pharmaceutical and cosmetical compositions comprising such oligonucleotide.
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公开(公告)号：EP4294921A1
公开(公告)日：2023-12-27
申请号：EP22706553.9
申请日：2022-02-10
发明人： SKOKOWA, Julia , NASRI, Masoud , MIR, Perihan
IPC分类号： C12N15/113
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公开(公告)号：EP4272555A1
公开(公告)日：2023-11-08
申请号：EP23171295.1
申请日：2023-05-03
发明人： HIRT, Bernhard , FEIL, Gerhard , KALBACHER, Hubert , PIETRZIK, Nikolas , GLEISER, Corinna , JUST, Lothar
摘要： The invention relates to the use of diamines according to formula (I), preferably according to formula (II), for interfering with function and/or structure of a polypeptide. In particular, the invention relates to the use of one or more of the diamines N -dodecyl-1,3-diamino propane (C12), N '-(3-aminopropyl)- N '-n-dodecyl-1,3-diamino propane (Bis-C12), N -(α-glutaminyl amido)- N '-n-dodecyl propane-1,3-diamine (α Glu-C12), N -(γ-glutaminyl amido)- N '-n-dodecyl propane-1,3-diamine (γGlu-C12) and N -oleyl-1,3-diamino propane (Oleyl-C12) for interfering with the function and/or the structure of polypeptides.
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公开(公告)号：EP4269609A1
公开(公告)日：2023-11-01
申请号：EP22170479.4
申请日：2022-04-28
发明人： Achberger, Kevin , Liebau, Stefan , Ossowski, Stephan , Buena Atienza, Elena , Admard, Jakob , Gross, Caspar
IPC分类号： C12Q1/6806 , C12Q1/6883 , C12Q1/6886
摘要： The present invention relates to a method for making a genetic determination based on a hair root sample, a kit adapted for carrying out said method, and to a use of a hair root sample from a test individual for making a genetic determination.
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公开(公告)号：EP4223877A1
公开(公告)日：2023-08-09
申请号：EP22155703.6
申请日：2022-02-08
IPC分类号： C12N15/113 , C12N9/22
摘要： The invention is directed to a gene editing system for editing genomic DNA to modulate splicing, a polynucleotide or vector encoding said gene editing system, a lipid particle comprising said gene editing system, a pharmaceutical composition comprising said gene editing system polynucleotide or vector or lipid particle, methods of editing genomic DNA in a cell to modulate splicing, and a cell processed by said methods.
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公开(公告)号：EP4198025A1
公开(公告)日：2023-06-21
申请号：EP21214773.0
申请日：2021-12-15
发明人： Schütz, Monika , Renschler, Fabian , Schweers, Jonas Malte , Autenrieth, Ingo , Poso, Antti , Kronenberger, Thales , Kurki, Milla , Turhanen, Petri , Leini, Renne , Schmidberger, Gregor
IPC分类号： C07D235/14 , C07D403/12 , A61K31/4184 , A61P31/04
摘要： The invention relates to a novel compound for the treatment and prophylaxis of a disease, especially a bacterial infectious disease, for reducing pathogen virulence and promoting host-induced clearance of infection and/or sensitizing bacteria to antibiotic treatment, a method for preparing said compound, a pharmaceutical composition comprising said compound, and to a method for the treatment and/or prophylaxis of a disease, preferably a bacterial infectious disease.
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